环境化学与生态毒理学国家重点实验室

近期成果

1.       Han-Zhang Wang, Yi-Ming Xiong, Shi-Lin Song, Qian-Cheng Zhao, Xuan-Yue Chen, Jing-Ran Gao, Yuan-Yuan Li*, Zhan-Fen Qin*. Low doses of chlorothalonil cause testicular impairment in mammals through the antimicrobial-like mechanism. Journal of Hazardous Materials, 2026, 506:141563.

2.       Yi-Ming Xiong, Xuan-Yue Chen, Han-Zhang Wang, Xing-Hong Li, Yuan-Yuan Li*, Zhan-Fen Qin. Screening and evaluation of male reproductive effects of isothiazolinones at human-relevant levels in mammals: direct impairments and increased susceptibility to subsequent spermatogenic stress. Environmental Science & Technology, 2025, 59:10812−10825.

3.       Cheng-Zhe Guo, Lin Lv, Xuan-Yue Chen, Han-Zhang Wang, Shi-Lin Song, Yuan-Yuan Li, Zhan-Fen Qin*. Low-dose bisphenol AF exerts slight effects on glycolipid metabolism but causes metabolic disorders under the stress of Western diet in mice. Environmental Pollution, 2025, 369:125861.

4.       Jie Li, Hai-Ming Xu, Xing-Hong Li, Yuan-Yuan Li*, Zhan-Fen Qin. Effects of environmentally relevant concentrations of carbendazim, either alone or combined with benzophenone-3, on testicular development in Xenopus laevis. Aquatic toxicology, 2025, 284:107393.

5.       Shi-Lin Song, Xuan-Yue Chen, Jun Zhao, Yuan-Yuan Li, Yi-Ming Xiong, Lin Lv, Jing Chang, Huili Wang, Xing Hong Li, Zhan-Fen Qin*. Effects of the fungicide prothioconazole on lipid metabolism in mice: Whitening alterations of brown adipose tissue. Environmental Science Technology, 2024, 58(41):18155-18166.

6.       Xuan-Yue Chen, Yuan-Yuan Li, Lin Lv, Yi-Ming Xiong, Zhan-Fen Qin*. The brominated flame retardant tetrabromobisphenol A-bis (2,3-dibromo-2-methylpropyl ether) as well as hexabromocyclododecane lead to lipid disorders in mice. Environmental Pollution, 2024, 341:122895.

7.       Yuan-Yuan Li, Zhe-Yuan Shi, Yi-Ming Xiong, Xuan-Yue Chen, Lin Lv, Honglin Huang, Wenbin Liu, Jing Zhao*, Xing Hong Li*, Zhan-Fen Qin. Bioaccumulation and male reproductive toxicity of the new brominated flame retardant tetrabromobisphenol A-bis(2,3-dibromo-2-methylpropyl ether) in comparison with hexabromocyclododecane. Environmental Science & Technology, 2024, 58(9):4127–4136.

8.       Xuan-Yue Chen, Yuan-Yuan Li, Zhan-Fen Qin*. Developing a novel quantitative parameter for characterizing spatial distribution of fish following exposure to chemicals and wastewater: Behavioral Gini coefficient. Journal of Environmental Sciences, 2024, 142:129-138.

9.       Yuan-Yuan Li, Yi-Ming Xiong, Xuan-Yue Chen, Jia-Yi Sheng, Lin Lv, Xing-Hong Li, Zhan-Fen Qin*. Extended exposure to tetrabromobisphenol A-bis(2,3-dibromopropyl ether) leads to subfertility in male mice at the late reproductive age. Archives of Toxicology, 2023, 97(11):2983-2995.

10.     Yi-Ming Xiong, Yuan-Yuan Li*, Lin Lv, Xuan-Yue Chen, Xing-Hong Li, Zhan-Fen Qin. Postnatal exposure to low-dose tetrabromobisphenol A increases the susceptibility of mammal testes to chemical-induced spermatogenic stress in adulthood. Environment International, 2023, 171:107683.

11.     Hong-Mei Li, Yuan-Yuan Li, Ying-Chi Zhang, Jin-Bo Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin*. Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis. Ecotoxicology and Environmental Safety. 2022, 236:113453.

12.     Hong-Mei Li, Ying-Chi Zhang, Yuan-Yuan Li*, Qing-Qing Zhu, Jie Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin. Low concentrations of benzophenone-type UV-filters impair testis development in the amphibian Xenopus laevis. Aquatic Toxicology, 2023, 254: 106371.

13.    Yuan-Yuan Li, Meng-Qi Dong, Yi-Ming Xiong, Qing Chang, Xuan-Yue Chen, Xu-Feng Fu, Xing-Hong Li, Zhan-Fen Qin*. Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events. Archives of Toxicology, 2022, 96(6):1881–1892.

14.    Yi-Ming Xiong, Xuan-Yue Chen, Feng Li, Zhao-Jing Chen, Zhan-Fen Qin*. Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test. Aquatic Toxicology, 2022, 246:106143.

15.    Yuan-Yuan Li, Jin-Bo Li, Yan-Ping Shen, Yi-Ming Xiong, Xing-Hong Li, Zhan-Fen Qin*. Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis. Aquatic Toxicology, 2021, 232:105760.

16.    Min Zhu, Yuan-Yuan Li, Yue Niu, Jin-Bo Li, Zhan-Fen Qin*. Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: A novel signaling by which bisphenols disrupt vertebrate development. Environmental Pollution, 2020, 263(Pt B):114443.

17.    Hai-Yan Pan, Ji-Fang-Tong Li, Xing-Hong Li*, You-Lin Yang, Zhan-Fen Qin, Jin-Bo Li, Yuan-Yuan Li. Transfer of dechlorane plus between human breast milk and adipose tissue and comparison with legacy lipophilic compounds. Environmental Pollution. 2020, 265: 115096.

18.    Man Cai, Yuan-Yuan Li, Min Zhu, Jin-Bo Li, Zhan-Fen Qin*. Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization. Environmental Pollution, 2020, 260:113980.

19.    Min Zhu, Xiao-Ying Chen, Yuan-Yuan Li, Nuo-Ya Yin, Francesco Faiola, Zhan-Fen Qin*, Wu-Ji Wei*. Bisphenol F disrupts thyroid hormone signaling and postembryonic development in Xenopus laevis. Environmental Science & Technology, 2018, 52:1602-1611.

20.    Zhan-Fen Qin, Jing-Ming Zhou, Shao-Gang Chu, Xiao-Bai Xu. Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis. Environmental Health Perspectives, 2003, 111(4):553-556.


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