环境化学与生态毒理学国家重点实验室

近期成果

1.      Chao XJ, Tang M, Huang R, Huang CH, Shao J, Yan ZY, Zhu B.Z.  (2019) Targeted Live-Cell Nuclear Delivery of the DNA ‘Light-switching’ Ru(II) Complex via Ion-Pairing with Chlorophenolate Counter-Anions: The Critical Role of Binding Stability and Lipophilicity of the Ion-Pairing Complexes. Nucleic Acids Res. doi: 10.1093/nar/gkz152

2.      Xu D, Huang CH, Xie LN, Shao B, Mao L, Shao J, Kalyanaraman B, Zhu BZ (2019) Mechanism of Unprecedented Hydroxyl Radical Production and Site-Specific Oxidative DNA Damage by Photo Activation of the Classic Arylhydroxamic Acid Carcinogens. Carcinogenesis doi: 10.1093/carcin/bgz021

3.      Sheng ZG, Shen C, Fan RM, Chao, Liu YX, Zhu BZ (2019) The Critical Role of X Chromosome-linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-phenanthroline Complex in Normal and Cancer Liver Cells. Toxicol. Sci., 168: 339-348.

4.      Xie LN, Shao J; Huang CH; Li F; Xu D; i Qin L; Kalyanaraman B, Zhu BZ (2019) An Unusual Double Radical Homolysis Mechanism for the Unexpected Activation of the Aldoxime Nerve-Agent Antidotes by Polyhalogenated Quinoid Carcinogens under Normal Physiological Conditions. Free Radic. Biol. Med. 130: 1-7.

5.      Sheng ZG, Wang C, Ren FR, Liu YX, Zhu BZ  (2019) The Molecular Mechanism of Endocrine-Disruptive Effects Induced by Bisphenol A: The Role of Transmembrane G-Protein Estrogen Receptor 1 and Integrin αvβ3. J. Environ. Sci. 75: 1-13. 

6.      Xie LN, Huang CH, Xu D, Li F, Zhu JG, Shen C, Shao B, Gao HY, Kalyanaraman B, Zhu BZ. (2017) Unusual double Beckmann fragmentation reaction under physiological conditions. J. Org. Chem. 82: 13084-13092.

7.      Gao H.Y., Mao L, Li F, Xie LN, Huang CH, Shao J, Shao B, Kalyanaraman B, and Zhu BZ (2017) Mechanism of intrinsic chemiluminescence production from the degradation of persistent chlorinated phenols by Fenton system: A structure-activity relationship study and the critical role of quinoid and semiquinone radical intermediates. Environ. Sci. Technol. 51: 2934-2943.

8.      Shao B., Mao L, Qu N, Wang YF, Gao HY, Li F, Qin L, Shao J, Huang CH, Xu D, Xie LN, Shen C, Zhou X and Zhu BZ (2017) Mechanism of synergistic DNA damage induced by the hydroquinone metabolite of brominated phenolic environmental pollutants and Cu(II): Formation of DNA-Cu complex and site-specific production of hydroxyl radicals Free Radic. Biol. Med. 104: 54-63.

9.      Li F, Huang CH, Xie LN, Qu N, Shao J, Shao B and Zhu BZ (2016) An exceptionally facile two-step structural isomerization and detoxication via a water-assisted double Lossen rearrangement. Sci. Rep. 6: 39207. doi: 10.1038/srep39207.

10.    Qu N, Li F, Shao B, Shao J, Zhai G, Wang F, Zhu BZ.  (2016) The unexpected and exceptionally facile chemical modification of the phenolic hydroxyl group of tyrosine by polyhalogenated quinones under physiological conditions. Chem. Res. Toxicol. 29: 1699-1705.

11.    Mao, L., Huang, C.H., Gao, H.Y., Kalyanaraman, B., Zhu, B.Z. (2015) Intrinsic chemiluminescence generation during advanced oxidation of persistent halogenated aromatic carcinogens. Environ. Sci. Technol. 49: 7940-7947.

12.    Huang, C.H.; Ren, F.R.; Shan, G.Q.; Qin, H.; Mao, L.; Zhu, B.Z. (2015) Molecular mechanism of metal-independent decomposition of organic hydroperoxides by the halogenated quinoid carcinogens and the potential biological implications. Chem. Res. Toxicol., 28, 831-837. (Cover story)

13.    Zhu B.Z., Hollenberg PF (2015) Chemical toxicology in China: A special issue. Chem. Res. Toxicol. 28: 279-280. (Guest Editor’s Editorial)

14.   Shan GQ, Yu A, Zhao CF, Huang CH, Zhu LY, Zhu B.Z. (2015) A combined experimental and computational investigation on the unusual molecular mechanism of the Lossen rearrangement reaction activated by carcinogenic halogenated quinones. J. Org. Chem. 80: 180-189.

15.   Li Y, Huang CH, Liu YX, Mao L, Zhu B.Z. (2014) Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure. Chem. Eur. J. 20: 13028-13033.

16.   Zhao B., et al., (2014) Redox-active quinones induce genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res. 42: 1593-1605.

17.   Qin H, Huang CH, Shan GQ, Mao L, Kalyanaraman B, Zhu B.Z. (2013) Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic. Biol. Med. 63: 459-466.

18.   Shao J, Huang CH, Kalyanaraman B, Zhu B.Z. (2013) Potent methyl oxidation of 5-methyl-2’-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic. Biol. Med. 60: 177-182.

19.   Yin R, Zhang D, Song Y, Zhu B.Z., Wang H (2013) Potent DNA damage by polyhalogenated quinoid carcinogens and H2O2 via a metal-independent and intercalation-enhanced oxidation mechanism. Sci. Rep. 3: 1269; doi: 10.1038/srep01269

20.   Huang CH, Shan GQ, Kalyanaraman B. Zhu B.Z. (2013) The first purification and unequivocal characterization of the unusual carbon-centered quinone ketoxy radical adduct. Chem. Commun. 49: 6436-6439.

21.   Sheng ZG, Li Y, Fan RM, Chao XJ, Zhu B.Z. (2013) Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex. Toxicol. Appl. Pharmacol. 266: 335-344.

22.   Zhu B.Z., Mao L., Huang C.H., Qin H., Fan R.M., Kalyanaraman B., Zhu J.G. (2012) Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2. Proc. Natl. Acad. Sci. USA 109: 16046-16051.

23.   Sheng Z.G., Zhu B.Z. (2011) Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G-protein-coupled receptor 30 and estrogen receptor-α. Environ. Health Perspect. 119: 1775-1780.

24.    Zhu B.Z., Zhu J.G., Fan R.M., Mao L. (2011) Metal-Independent Pathways of Chlorinated Phenol/Quinone Toxicity. Advances in Molecular Toxicology (Ed. J. C. Fishbein) Vol. 5, pp 1-43. (Invited Book Chapter)

25.    Zhu B.Z., Mao L., Fan R.M., Zhu J.G. Zhang Y.N., Wang J., Kalyanaraman B., Frei B. (2011) Ergothioneine prevents copper-induced oxidative damage to DNA and protein by formation of a redox-inactive ergothioneine-copper complex. Chem. Res. Toxicol. 24: 30-34.

26.   Zhu B.Z., Zhu J.G., Kalyanaraman B., Mao L. and Shan G.Q. (2010) Detoxifying polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement. Proc. Natl. Acad. Sci. USA 107: 20286-20290.

27.    Zhu B.Z. and Shan G.Q. (2009) Potential mechanism for pentachlorophenol-induced carcinogenicity: A novel mechanism for metal-independent production of hydroxyl radicals. Chem. Res. Toxicol. 22: 969-977. (Invited Perspective)

28.   Zhu B.Z., Shan G.Q., Huang C.H. and Kalyanaraman B. (2009) Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical. Proc. Natl. Acad. Sci. USA 106: 11466-11471.

29.   Zhu B.Z., Kalyanaraman B. and Jiang G.B. (2007) Molecular Mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 17575-17578.

30.   Zhu B.Z., Zhao H.T., Kalyanaraman B. Liu J., Shan G.Q., Du Y.G. and Frei B. (2007) Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 3698-3702.

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