简历：

教育经历 

1999/9–2002/7，中国科学院生态环境研究中心，环境科学，博士，导师: 徐晓白 

1996/9–1999/7, 协和医科大学, 医学微生物, 硕士, 导师: 季阳 

1991/9–1995/7, 河北大学, 环境生物学, 学士, 导师: 康现江 

工作经历 

2013/12-至今, 中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 研究员，博导 

2006/7-2013/12，中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 副研，硕导

 2004/10-2006/6，中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 助研 

1995/10-1996/8, 河北省保定市环境保护局, 监测站, 科员 

2002/7-2004/9, 中国科学院生物物理研究所, 博士后, 合作导师: 杨福愉

社会任职：

全国危险化学品管理标准化技术委员会化学品毒性检测分技术委员会委员 

中国环境科学学会化学品环境风险防控专业委员会常务委员

承担科研项目：

1. 国家自然科学基金面上项目，亲脂性污染物对膳食脂质经肠淋巴吸收的影响、机制及其与脂代谢失调的关系，2026/01-2029/12，主持。 

2. 国家自然科学基金面上项目，杀菌剂类污染物单一暴露和复合暴露的雄性生殖毒性及对睾丸损伤易感性的影响，2023/01-2026/12，主持。 

3. 生态环境部项目：新污染物环境风险评估项目，2024/07-2024/12，参加。 

4. 中国科学院战略性先导专项（B类），新污染物的暴露组与毒性效应机制, 2023/12至2028/11，参加。 

5. 国家自然科学基金面上项目，双酚类物质对脊椎动物肠发育和吸收功能的影响和机制，2021/01-2024/12，主持。 

6. 国家重点研发计划项目，高灵敏环境持久性有毒污染物感知与识别生物系统，2019/07-2024/06，参加。 

7. 国家重点研发计划项目-课题，2017YFF0211203，化学品水生毒性测试新物种和快速分级技术研究，2017/07-2021/12，主持。 

8. 中国科学院先导科技专项《典型污染物的环境暴露与健康危害机制》，XDB14040102，甲状腺激素信号介导的化学污染物脑发育毒性研究，2014/7-2019/7，参加。

9. 中国科学院前沿科学重点研究项目-课题，PBDEs对非洲爪蟾的生殖发育毒性及其机制，2017/01-2021/12，主持。 

10. 国家自然科学基金面上项目，21876196，双酚类化合物的神经发育毒性及多信号介导的分子机制，2019/01-2022/12，主持。 

11. 国家自然科学基金面上项目，21677166，环境雌激素诱导两栖动物雌性化的分子机制研究，2017/01-2020/12，主持。

获奖及荣誉：

2021年度朱李月华优秀教师奖 

2013年度中国科学院杰出科技成就奖（集体奖）

代表论著：

1.       Han-Zhang Wang, Yi-Ming Xiong, Shi-Lin Song, Qian-Cheng Zhao, Xuan-Yue Chen, Jing-Ran Gao, Yuan-Yuan Li*, Zhan-Fen Qin*. Low doses of chlorothalonil cause testicular impairment in mammals through the antimicrobial-like mechanism. Journal of Hazardous Materials, 2026, 506:141563.

2.       Yi-Ming Xiong, Xuan-Yue Chen, Han-Zhang Wang, Xing-Hong Li, Yuan-Yuan Li*, Zhan-Fen Qin. Screening and evaluation of male reproductive effects of isothiazolinones at human-relevant levels in mammals: direct impairments and increased susceptibility to subsequent spermatogenic stress. Environmental Science & Technology, 2025, 59:10812−10825.

3.       Cheng-Zhe Guo, Lin Lv, Xuan-Yue Chen, Han-Zhang Wang, Shi-Lin Song, Yuan-Yuan Li, Zhan-Fen Qin*. Low-dose bisphenol AF exerts slight effects on glycolipid metabolism but causes metabolic disorders under the stress of Western diet in mice. Environmental Pollution, 2025, 369:125861.

4.       Shi-Lin Song, Xuan-Yue Chen, Jun Zhao, Yuan-Yuan Li, Yi-Ming Xiong, Lin Lv, Jing Chang, Huili Wang, Xing Hong Li, Zhan-Fen Qin*. Effects of the fungicide prothioconazole on lipid metabolism in mice: Whitening alterations of brown adipose tissue. Environmental Science Technology, 2024, 58(41):18155-18166.

5.       Xuan-Yue Chen, Yuan-Yuan Li, Lin Lv, Yi-Ming Xiong, Zhan-Fen Qin*. The brominated flame retardant tetrabromobisphenol A-bis (2,3-dibromo-2-methylpropyl ether) as well as hexabromocyclododecane lead to lipid disorders in mice. Environmental Pollution, 2024, 341:122895.

6.       Hong-Mei Li, Yuan-Yuan Li, Ying-Chi Zhang, Jin-Bo Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin*. Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis. Ecotoxicology and Environmental Safety. 2022, 236:113453.

7.       Yuan-Yuan Li, Yi-Ming Xiong, Xuan-Yue Chen, Jia-Yi Sheng, Lin Lv, Xing-Hong Li, Zhan-Fen Qin*. Extended exposure to tetrabromobisphenol A-bis(2,3-dibromopropyl ether) leads to subfertility in male mice at the late reproductive age. Archives of Toxicology, 2023, 97(11):2983-2995.

8.       Yi-Ming Xiong, Yuan-Yuan Li*, Lin Lv, Xuan-Yue Chen, Xing-Hong Li, Zhan-Fen Qin. Postnatal exposure to low-dose tetrabromobisphenol A increases the susceptibility of mammal testes to chemical-induced spermatogenic stress in adulthood. Environment International, 2023, 171:107683.

9.       Yuan-Yuan Li, Meng-Qi Dong, Yi-Ming Xiong, Qing Chang, Xuan-Yue Chen, Xu-Feng Fu, Xing-Hong Li, Zhan-Fen Qin*. Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events. Archives of Toxicology, 2022, 96(6):1881–1892.

10.     Yi-Ming Xiong, Xuan-Yue Chen, Feng Li, Zhao-Jing Chen, Zhan-Fen Qin*. Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test. Aquatic Toxicology, 2022, 246:106143.

11.     Yuan-Yuan Li, Jin-Bo Li, Yan-Ping Shen, Yi-Ming Xiong, Xing-Hong Li, Zhan-Fen Qin*. Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis. Aquatic Toxicology, 2021, 232:105760.

12.     Min Zhu, Yuan-Yuan Li, Yue Niu, Jin-Bo Li, Zhan-Fen Qin*. Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: A novel signaling by which bisphenols disrupt vertebrate development. Environmental Pollution, 2020, 263 (Pt B):114443.

13.     Man Cai, Yuan-Yuan Li, Min Zhu, Jin-Bo Li, Zhan-Fen Qin*. Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization. Environmental Pollution, 2020, 260:113980.

14.     Min Zhu, Xiao-Ying Chen, Yuan-Yuan Li, Nuo-Ya Yin, Francesco Faiola, Zhan-Fen Qin*, Wu-Ji Wei*. Bisphenol F disrupts thyroid hormone signaling and postembryonic development in Xenopus laevis. Environmental Science & Technology, 2018, 52:1602-1611.

15.     Zhan-Fen Qin, Jing-Ming Zhou, Shao-Gang Chu, Xiao-Bai Xu. Effects of Chinese domestic polychlorinated biphenyls (PCBs) on gonadal differentiation in Xenopus laevis. Environmental Health Perspectives, 2003, 111(4):553-556.