李圆圆

简历:
2023/01-至今,中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 副研究员
2019/6-2023/01,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,助理研究员
2017/8-2019/5, 中国科学院生态环境研究中心, 博士后,合作导师:郑明辉/秦占芬 研究员
2012/9–2017/7,中国科学院生态环境研究中心,环境科学,博士,导师: 秦占芬
2007/9–2011/7, 太原科技大学, 环境科学, 学士
社会任职:
中国化学会会员、中国毒理学会会员、中国动物学会会员
承担科研项目:
1. 国家自然科学基金面上项目,亲电性杀菌剂的高杀精作用及巯基介导的机制,2027/01-2030/12,主持。
2. 中国科学院战略性先导专项(B类),新污染物的暴露组与毒性效应机制, 2023/12 至 2028/11, 参加。
3. 国家自然科学基金青年项目,胞外基质参与环境雌激素诱导两栖动物雌性化的机制研究,2020/01-2021/12,主持。
4. 博士后科学基金面上项目,环境雌激素诱导两栖动物雌性化的有害结局路径,2017/11-2019/05,主持。
获奖及荣誉:
2016年教育部博士研究生国家奖学金
2014年教育部硕士研究生国家奖学金
2010年教育部本科生国家奖学金
代表论著:
1. Han-Zhang Wang, Yi-Ming Xiong, Shi-Lin Song, Qian-Cheng Zhao, Xuan-Yue Chen, Jing-Ran Gao, Yuan-Yuan Li*, Zhan-Fen Qin*. Low doses of chlorothalonil cause testicular impairment in mammals through the antimicrobial-like mechanism. Journal of Hazardous Materials, 2026, 506:141563.
2. Yi-Ming Xiong, Xuan-Yue Chen, Han-Zhang Wang, Xing-Hong Li, Yuan-Yuan Li*, Zhan-Fen Qin. Screening and evaluation of male reproductive effects of isothiazolinones at human-relevant levels in mammals: direct impairments and increased susceptibility to subsequent spermatogenic stress. Environmental Science & Technology 2025, 59:10812−10825.
3. Jie Li, Hai-Ming Xu, Xing-Hong Li, Yuan-Yuan Li*, Zhan-Fen Qin. Effects of environmentally relevant concentrations of carbendazim, either alone or combined with benzophenone-3, on testicular development in Xenopus laevis. Aquatic toxicology 2025, 284:107393.
4. Qiancheng Zhao, Zishui Fang, Pengcheng Wang, Zhenwei Qian , Yuzhuo Yang, LingxiangRan, Jiachen Zheng, Yanlin Tang, Xuejing Cui, Yuan-Yuan Li*, Zhe Zhang*, and Hui Jiang*. Polylactic acid micro/nanoplastic exposure induces male reproductive toxicity by disrupting spermatogenesis and mitochondrial dysfunction in mice. ACS Nano. 2025, 19(5):5589-5603.
5. Yuan-Yuan Li, Zhe-Yuan Shi, Yi-Ming Xiong, Xuan-Yue Chen, Lin Lv, Hong-Lin Huang, Wen-Bin Liu, Jing Zhao*, Xing-Hong Li*, Zhan-Fen Qin. Bioaccumulation and male reproductive toxicity of the new brominated flame retardant tetrabromobisphenol A-bis(2,3-dibromo-2-methylpropyl ether) in comparison with hexabromocyclododecane. Environmental Science & Technology 2024, 58(9):4127–4136.
6. Yuan-Yuan Li, Yi-Ming Xiong, Shu-Yan Zhang, Jing-Lin Deng, Qiao Xue, Xing-Wang Hou, Wen-Bin Liu, Xing-Hong Li, Zhan-Fen Qin. Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) impairs postnatal testis development in mice: the Microtubule cytoskeleton as a sensitive target. Environment & Health, 2023, 1:168-179.
7. Yi-Ming Xiong, Yuan-Yuan Li*, Lin Lv, Xuan-Yue Chen, Xing-Hong Li, Zhan-Fen Qin. Postnatal exposure to low-dose tetrabromobisphenol A increases the susceptibility of mammal testes to chemical-induced spermatogenic stress in adulthood. Environment International, 2023, 171: 107683.
8. Hong-Mei Li, Ying-Chi Zhang, Yuan-Yuan Li*, Qing-Qing Zhu, Jie Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin. Low concentrations of benzophenone-type UV-filters impair testis development in the amphibian Xenopus laevis. Aquatic Toxicology, 2023, 254: 106371.
9. Yuan-Yuan Li, Meng-Qi Dong, Yi-Ming Xiong, Qing Chang, Xuan-Yue Chen, Xu-Feng Fu, Xing-Hong Li, Zhan-Fen Qin*. Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events. Archives of Toxicology, 2022, 96(6):1881-1892
10. Yuan-Yuan Li, Jin-Bo Li, Yan-Ping Shen, Yi-Ming Xiong, Xing-Hong Li, Zhan-Fen Qin*. Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis. Aquatic Toxicology, 2021, 232: 105760.