环境化学与生态毒理学国家重点实验室

李圆圆

发布时间:2019-06-04  |  【打印】 【关闭

姓名:李圆圆性别:女职称:副研究员电话:010-62919177E-mail:yyli@rcees.ac.cn组别:内分泌干扰物与发育毒性研究组研究方向:生殖内分泌干扰招生专业:环境科学

简历:

2023/01-至今,中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 副研究员 

2019/6-2023/01,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,助理研究员 

2017/8-2019/5, 中国科学院生态环境研究中心, 博士后,合作导师:郑明辉/秦占芬 研究员 

2012/9–2017/7,中国科学院生态环境研究中心,环境科学,博士,导师: 秦占芬 

2007/9–2011/7, 太原科技大学, 环境科学, 学士

社会任职:

中国化学会会员、中国毒理学会会员、中国动物学会会员

承担科研项目:

1. 国家自然科学基金面上项目,亲电性杀菌剂的高杀精作用及巯基介导的机制,2027/01-2030/12,主持。 

2. 中国科学院战略性先导专项(B类),新污染物的暴露组与毒性效应机制, 2023/12 至 2028/11, 参加。 

3. 国家自然科学基金青年项目,胞外基质参与环境雌激素诱导两栖动物雌性化的机制研究,2020/01-2021/12,主持。 

4. 博士后科学基金面上项目,环境雌激素诱导两栖动物雌性化的有害结局路径,2017/11-2019/05,主持。

获奖及荣誉:

2016年教育部博士研究生国家奖学金 

2014年教育部硕士研究生国家奖学金 

2010年教育部本科生国家奖学金

代表论著:

1.Han-Zhang Wang, Yi-Ming Xiong, Shi-Lin Song, Qian-Cheng Zhao, Xuan-Yue Chen, Jing-Ran Gao, Yuan-Yuan Li*, Zhan-Fen Qin*. Low doses of chlorothalonil cause testicular impairment in mammals through the antimicrobial-like mechanism. Journal of Hazardous Materials, 2026, 506:141563.

2.Yi-Ming Xiong, Xuan-Yue Chen, Han-Zhang Wang, Xing-Hong Li, Yuan-Yuan Li*, Zhan-Fen Qin. Screening and evaluation of male reproductive effects of isothiazolinones at human-relevant levels in mammals: direct impairments and increased susceptibility to subsequent spermatogenic stress. Environmental Science & Technology 2025, 59:10812−10825.

3.Jie Li, Hai-Ming Xu, Xing-Hong Li, Yuan-Yuan Li*, Zhan-Fen Qin. Effects of environmentally relevant concentrations of carbendazim, either alone or combined with benzophenone-3, on testicular development in Xenopus laevis. Aquatic toxicology 2025, 284:107393.

4.Qiancheng Zhao, Zishui Fang, Pengcheng Wang, Zhenwei Qian , Yuzhuo Yang, LingxiangRan, Jiachen Zheng, Yanlin Tang, Xuejing Cui, Yuan-Yuan Li*, Zhe Zhang*, and Hui Jiang*. Polylactic acid micro/nanoplastic exposure induces male reproductive toxicity by disrupting spermatogenesis and mitochondrial dysfunction in mice. ACS Nano. 2025, 19(5):5589-5603.

5.Yuan-Yuan Li, Zhe-Yuan Shi, Yi-Ming Xiong, Xuan-Yue Chen, Lin Lv, Hong-Lin Huang, Wen-Bin Liu, Jing Zhao*, Xing-Hong Li*, Zhan-Fen Qin. Bioaccumulation and male reproductive toxicity of the new brominated flame retardant tetrabromobisphenol A-bis(2,3-dibromo-2-methylpropyl ether) in comparison with hexabromocyclododecane. Environmental Science & Technology 2024, 58(9):4127–4136.

6.Yuan-Yuan Li, Yi-Ming Xiong, Shu-Yan Zhang, Jing-Lin Deng, Qiao Xue, Xing-Wang Hou, Wen-Bin Liu, Xing-Hong Li, Zhan-Fen Qin. Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) impairs postnatal testis development in mice: the Microtubule cytoskeleton as a sensitive target. Environment & Health, 2023, 1:168-179.

7.Yi-Ming Xiong, Yuan-Yuan Li*, Lin Lv, Xuan-Yue Chen, Xing-Hong Li, Zhan-Fen Qin. Postnatal exposure to low-dose tetrabromobisphenol A increases the susceptibility of mammal testes to chemical-induced spermatogenic stress in adulthood. Environment International, 2023, 171: 107683.

8.Hong-Mei Li, Ying-Chi Zhang, Yuan-Yuan Li*, Qing-Qing Zhu, Jie Li, Hai-Ming Xu, Yi-Ming Xiong, Zhan-Fen Qin. Low concentrations of benzophenone-type UV-filters impair testis development in the amphibian Xenopus laevis. Aquatic Toxicology, 2023, 254: 106371.

9.Yuan-Yuan Li, Meng-Qi Dong, Yi-Ming Xiong, Qing Chang, Xuan-Yue Chen, Xu-Feng Fu, Xing-Hong Li, Zhan-Fen Qin*. Effects of postnatal exposure to tetrabromobisphenol A on testis development in mice and early key events. Archives of Toxicology, 2022, 96(6):1881-1892

10.Yuan-Yuan Li, Jin-Bo Li, Yan-Ping Shen, Yi-Ming Xiong, Xing-Hong Li, Zhan-Fen Qin*. Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis. Aquatic Toxicology, 2021, 232: 105760.


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