2019年11月27日，应Francesco Faiola研究员邀请，来自西班牙国立圣地亚哥大学（Universidade de Santiago de Compostela）的Miguel Fidalgo教授和Diana Guallar教授到生态环境研究中心访问并分别作了题为《Circadian clock-independent functions of BMAL1 in regulation of pluripotent stem cells differentiation》和《Loss of A-to-I RNA editing activity impairs mesenchymal-to-epithelial transition by aberrant activation of Endoplasmic Reticulum stress》的学术报告。

　　报告由环境化学与生态毒理学国家重点实验室Francesco Faiola研究员主持。报告主要介绍了两部分工作：BMAL1节律蛋白在多能干细胞分化过程中通过调控能量代谢进而影响细胞命运决定；以及依赖RNA编辑酶ADAR1催化的Adenosine转化为Inosine的过程可以通过影响内质网应激状态从而调控细胞命运。两位西班牙教授深入浅出的对干细胞分子前沿研究进行介绍，针对报告中的内容及技术，参会老师和同学与两位西班牙教授进行了深入的交流与讨论。

　　会后，两位教授就欧洲目前干细胞发展现状和未来趋势进行了简要介绍，鼓励有兴趣的同学未来到欧洲进行博士后研究。西班牙圣地亚哥大学（Universidade de Santiago de Compostela）成立于1495年，有着超过500年的悠久历史，在生物、医学、法律、语言学等领域享有声望。

　　On November 27, 2019, on behalf of SKLECE, Prof. Francesco Faiola invited Miguel Fidalgo and Diana Guallar, two prestigious professors from Universida de Santiago de Compostela, Spain, to visited Research Center for Eco-Environmental Sciences, CAS. Professors from both sides exchanged views on the current situation of stem cell research, and Spanish professors gave academic seminars on current research hot topics.

　　In the meeting, Prof. Faiola introduced the two Spanish professors’ background and current status, then followed by two wonderful talks: “circadian clock-independent functions of BMAL1 in regulation of pluripotent stem cells differentiation”, and “loss of A-To-I RNA editing activity impairs mesenchymal-to-epithelial transition by aberrant activation of endoplasmic reticulum stress”. The two Spanish professors introduced the frontier research of stem cell molecules in a simple way. The participants had in-depth exchanges and discussions with the two Spanish professors.

　　After the seminars, the two Spanish professors briefly introduced the current situation and future trend of stem cell development in Europe, and encouraged interested students to conduct post-doctoral research in Europe in the future. Founded in 1495, Universidade de Santiago de Compostela has a long history of more than 500 years and enjoys a reputation in biology, medicine, law, linguistics and other fields.

Miguel Fidalgo研究员回答观众问题

Diana Guallar研究员进行报告