宋杨
简历:
教育经历
2001/09-2006/10,武汉大学,化学与分子科学学院,博士
1997/09-2001/07,武汉大学,化学与分子科学学院,学士
工作经历
2021/05-至今,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,研究员,博士生导师
2008/12-2021/04,西南大学,药学院,教授,博士生导师
2012/08-2013/02,美国佛罗里达大学,化学学院,高级访问学者
2009/10-2010/03,美国爱荷华大学,医学院,访问学者
2006/10-2008/12,美国爱荷华大学,公共卫生学院/医学院,博士后
社会任职:
1. 中国活性氧生物学效应专业委员会青年主任委员
2. 中国环境科学学会环境化学分会委员
3. 中国毒理学会青年委员会委员
4. 《Chem Res Toxicol》客座编辑
5. 《环境化学》期刊青年编委
承担科研项目:
1. 国家自然科学基金面上项目,多氯联苯醌通过活性氧机制调控肿瘤微环境促进转移和侵袭的信号过程,2020-2023,主持
2. 国家自然科学基金委优秀青年基金,环境毒理与健康效应,2017-2019,主持
3. 国家自然科学基金面上项目,多氯联苯醌引起的氧化应激相关信号转导与神经毒性作用机制及抗氧化剂干预,2015-2018,主持
4. 国家自然科学基金青年基金,寻找多氯联苯代谢途径中缺失的一环,2010-2012,主持
5. 教育部新世纪优秀人才支持计划,2010-2012,主持
6. 科技部重大新药创制科技重大专项子项目,抗肿瘤药巯环磷酰胺的临床前研究,2010-2012,主持
7. 教育部留学回国人员科研启动基金,由多氯联苯及其衍生物引发的自由基及其毒性关系研究,2011-2014,主持
8. 重庆市自然科学基金,具有双重功能的抗肿瘤活化前药的设计,合成及生物活性研究,2009-2012,主持
获奖及荣誉:
1. 中国毒理学会优秀青年科技奖,2020
2. 国家自然科学基金委优秀青年基金,2016
3. 中国科学院青年联合会“寻找青年科学之星”,2012
4. 教育部新世纪优秀人才支持计划,2009
代表论著:
1. Xuting Liu, Wei Wei, Zixuan Liu, Erqun Song, Jianlin Lou, Lingfang Feng, Rongchong Huang, Chunying Chen, Pu Chun Ke, Yang Song*, Serum apolipoprotein A-I depletion is causative to silica nanoparticles–induced cardiovascular damage, Proceedings of the National Academy of Sciences of the United States of America, 2021, e2108131118
2. Ya Tan, Xiangyu Zhu, Di Wu, Erqun Song, Yang Song*, Compromised autophagic effect of polystyrene nanoplastics mediated by protein corona was recovered after lysosomal degradation of corona, Environmental Science & Technology, 2020, 54, 11485-11493
3. Zixuan Liu, Xuying Lv, Lei Xu, Xuting Liu, Xiangyu Zhu, Erqun Song and Yang Song*, Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation, Particle and Fibre Toxicology, 2020, 17, 46
4. Jing Liu, Ya Tan, Bingwei Yang, Yunjie Wu, Bailing Fan, Sixi Zhu, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression, Environment International, 2020, 139, 105701
5. Changping Zhang, Zixuan Liu, Yuhao Zhang, Liang Ma, Erqun Song and Yang Song*, “Iron free”zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis, Cell Death & Disease, 2020, 11, 183
6. Lu Peng, Xiangyu Zhu, Zongming Qin, Jing Liu, Erqun Song, Yang Song*, Polychlorinated Biphenyl Quinone Metabolite Causes Neutrophil Extracellular Traps in Mouse Bone Marrow Neutrophil, Chemical Research in Toxicology, 2022, 10.1021/acs.chemrestox.1c00375
7. Xiangyu Zhu, Lu Peng, Erqun Song, Yang Song*, Polystyrene Nanoplastics Induce Neutrophil Extracellular Traps in Mice Neutrophils, Chemical Research in Toxicology, 2022, 10.1021/acs.chemrestox.1c00374
8. Qi Qin, Bingwei Yang, Jing Liu, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone exposure promotes breast cancer aerobic glycolysis: An in vitro and in vivo examination, Journal of Hazardous Materials, 2022, 127512
9. Yunxiang Sun,* Aleksandr Kakinen, Xulin Wan, Niamh Moriarty, Cameron P.J. Hunt, Yuhuan Li, Nicholas Andrikopoulos, Aparna Nandakumar, Thomas P. Davis, Clare L. Parish, Yang Song*, Pu Chun Ke* and Feng Ding*, Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer’s Amyloid Beta, Nano Today, 2021, 38, 101125
10. Di Wu, Xiangyu Zhu, Jian Ao, Erqun Song, Yang Song*, Delivery of ultrasmall nanoparticles to the cytosolic compartment of pyroptotic J774A.1 macrophages via GSDMDNterm membrane pores, ACS Appl Mater Interfaces, 2021, 13, 50823-50835
11. Myeongsang Lee, Nengyi Ni, Huayuan Tang, Yuhuan Li, Wei Wei, Aleksandr Kakinen, Xulin Wan, Thomas P. Davis, Yang Song,* David Tai Leong,* Feng Ding,* and Pu Chun Ke*, A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness, Advanced Science, 2021, e2102519
12. Lei Xu, Yuting Wang, Erqun Song, Yang Song*, Nucleophilic and redox properties of polybrominated diphenyl ether derived-quinone/hydroquinone metabolites are responsible for their neurotoxicity, Journal of Hazardous Materials, 2021, 420, 126697
13. Zixuan Liu, Xiaomin Xia, Xuying Lv, Erqun Song, Yang Song*, Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level, Environmental Pollution, 2021, 117345
14. Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Song*, Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells, Toxicology, 2021, 457, 152807
15. Zixuan Liu, Qiushuang Zhu, Erqun Song, Yang Song*, Characterization of blood protein adsorption on PM2.5 and its implications on cellular uptake and cytotoxicity of PM2.5, Journal of Hazardous Materials, 2021, 414, 125499
16. Yuting Wang, Lei Xu, Lu Peng, Changyu Fang, Qi Qin, Xuying Lv, Zixuan Liu, Bingwei Yang, Erqun Song, Yang Song*, Polybrominated diphenyl ethers quinone-induced intracellular protein oxidative damage triggers ubiquitin-proteasome and autophagy-lysosomal system activation in LO2 cells, Chemosphere, 2021, 275, 130034
17. Qifang Chen, Xianbin Ma, Li Xie, Wenjie Chen, Zhigang Xu, Erqun Song, Xiaokang Zhu*, Yang Song*, Iron-Based Nanoparticles for MR Imaging-Guided Ferroptosis in Combination with Photodynamic Therapy to Enhance Cancer Treatment, Nanoscale, 2021, 13, 4855-4870
18. Xiaoqi Tao, Xulin Wan, Di Wu, Erqun Song, Yang Song*, A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774a.1 macrophage, Journal of Hazardous Materials, 2021, 411, 125134
19. Qiushuang Zhu, Zixuan Liu, Yuting Wang, Erqun Song, Yang Song*, Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells, Journal of Hazardous Materials, 2021, 411, 124958
20. Wenjing Dong, Erqun Song, Yang Song*, Co-administration of lipopolysaccharide and D-galactosamine induces genotoxicity in mouse liver, Scientific Reports, 2021, 11, 1733
21. Lihui Zhang, Wei Wei, Zixuan Liu, Xuting Liu, Erqun Song, Yang Song*, Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization, Journal of Hazardous Materials, 2021, 124467
22. Xuting Liu, Bin Lu, Juanli Fu, Xiaokang Zhu, Erqun Song, Yang Song*, Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells, Journal of Hazardous Materials, 2021, 404, 124050
23. Zixuan Liu, Xuying Lv, Bingwei Yang, Qi Qin, Erqun Song, Yang Song*, Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity, Chemosphere, 2021, 264, 128413
24. Qi Qin, Bingwei Yang, Zixuan Liu, Lei Xu, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone induced the acquisition of cancer stem cells properties and epithelial-mesenchymal transition through Wnt/β-catenin, Chemosphere, 2021, 263, 128125
25. Lu Peng, Yawen Wang, Bingwei Yang, Qi Qin, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone regulates MLKL phosphorylation that stimulates exosome biogenesis and secretion via a short negative feedback loop, Environmental Pollution, 2021, 274, 115606
26. Xuying Lv, Zixuan Liu, Lei Xu, Erqun Song, Yang Song*, Tetrachlorobenzoquinone exhibits immunotoxicity by inducing neutrophil extracellular traps through a mechanism involving ROS-JNK-NOX2 positive feedback loop, Environmental Pollution, 2021, 268, 115921
27. Nicholas Andrikopoulos, Zhiyuan Song, Xulin Wan, Alon M. Douek, Ibrahim Javed, Changkui Fu, Yanting Xing, Fangyun Xin, Yuhuan Li, Aleksandr Kakinen, Kairi Koppel, Ruirui Qiao, Andrew K. Whittaker, Jan Kaslin, Thomas P. Davis,* Yang Song,* Feng Ding,* and Pu Chun Ke,*, Inhibition of amyloid aggregation and toxicity with janus iron oxide nanoparticles, Chemistry of Materials, 2021, 33, 16, 6484-6500
28. Aparna Nandakumar, Wei Wei, Ghizal Siddiqui, Huayuan Tang, Yuhuan Li, Aleksandr Kakinen, Xulin Wan, Kairi Koppel, Sijie Lin, Thomas P. Davis, David T. Leong, Darren J. Creek, Feng Ding, Yang Song*, and Pu Chun Ke*, Dynamic protein corona of gold nanoparticles with an evolving morphology, ACS Appl Mater Interfaces, 2021, 13, 58238-58251
29. Yuting Wang, Changyu Fang, Lei Xu, Bingwei Yang, Erqun Song, Yang Song*, Polybrominated diphenyl ether quinone exposure induces atherosclerosis progression via CD36-mediated lipid accumulation, NLRP3 inflammasome activation, and pyroptosis, Chemical Research in Toxicology, 2021, 34, 2125-2134
30. Linyao Li, Peilin Gu, Mengqi Hao, Xiaoli Xiang, Yuting Feng, Xiaokang Zhu, Yang Song, Erqun Song*, Bacteria-targeted mri probe-based imaging bacterial infection and monitoring antimicrobial therapy in vivo, Small, 2021, e2103627
31. Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed, Aleksandr Kakinen, Sijie Lin, Tian Xia, Yang Song, Thomas P. Davis, Iseult Lynch, Wolfgang J. Parak, David Tai Leong, Pu Chun Ke*, Chunying Chen*, and Yuliang Zhao, Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade, Nano Today, 2021, 39, 101184
32. Xiaoqi Tao, Ziyi Liao, Yaqing Zhang, Fei Fua, Mengqi Hao, Yang Song, Erqun Song*, Aptamer-quantum dots and teicoplanin-gold nanoparticles constructed FRET sensor for sensitive detection of Staphylococcus aureus, Chinese Chemical Letters, 2021, 791-795
33. Ziyi Liao, Lan Han, Qingjin Li, Linyao Li, Yuan Liu, Yang Song, Weihong Tan, Erqun Song*, Gradient magnetic separation and fluorescent imaging-based heterogeneous circulating tumor cell subpopulations assay with biomimetic multifunctional nanoprobes. Advanced Functional Materials, 2021, 2009937
34. Yunyun Hu, Xin Guo, Peilin Gu, Qin Luo, Yang Song, Erqun Song*, Mn2+-mediated magnetic relaxation switching for direct assay of ctDNA in whole blood via exonuclease III assisted amplification, Sensors and Actuators B: Chemical, 2021, 330, 129340
35. Qingjin Li, Ziyi Liao, Lan Han, Linyao Li, Yang Song, Erqun Song*, Isolation and analysis of tumor cell subpopulations using biomimetic immuno-fluorescent magnetic multifunctional nanoprobes, Advanced Functional Materials, 2020, 2004963
36. Xiaoqi Tao, Xiaoxi Chang, Xulin Wan, Yina Guo, Yaqing Zhang, Ziyi Liao, Yang Song*, Erqun Song*, Impact of protein corona on noncovalent molecule-gold nanoparticle-based sensing, Analytical Chemistry, 2020, 92, 14990-14998
37. Zixuan Liu, Xuying Lv, Erqun Song, Yang Song*, Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis, Toxicology and Applied Pharmacology, 2020, 407, 115241
38. Fei Fu, Yaqing Zhang, Linyao Li, Hong Wang, Qingjin Li, Xiaoqi Tao, Yang Song, Erqun Song*, Intracellular Pathogen Detection Based on Dual-Recognition Units Constructed Fluorescence Resonance Energy Transfer Nanoprobe, Analytical Chemistry, 2020, 92, 11462-11468
39. Yunyun Hu, Xin Guo, Hong Wang, Qin Luo, Yang Song, and Erqun Song*, Magnetic-Separation-Assisted Magnetic Relaxation Switching Assay for Mercury Ion Based on the Concentration Change of Oligonucleotide-Functionalized Magnetic Nanoparticle, ACS Applied Bio Materials, 2020, 3, 2651-2657
40. Jing Liu, Ya Tan, Erqun Song, Yang Song*, A Critical Review of Polychlorinated Biphenyls Metabolism, Metabolites and Their Correlation with Oxidative Stress. Chemical Research in Toxicology, 2020, 33, 2022-2042
41. Bingwei Yang, Qi Qin, Lei Xu, Xuying Lv, Zixuan Liu, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone promotes atherosclerosis through lipid accumulation and endoplasmic reticulum stress via CD36. Chemical Research in Toxicology, 2020, 33, 1497-1507
42. Jing Liu, Bingwei Yang, Yuting Wang, Yunjie Wu, Bailing Fan, Sixi Zhu, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone promotes macrophage polarization to CD163+ cells through Nrf2 signaling pathway, Environmental Pollution, 2020, 257, 113587
43. Wenjing Dong, Ya Tan, Qi Qin, Bingwei Yang, Qiushuang Zhu, Lei Xu, Zixuan Liu, Erqun Song, Yang Song*, Polybrominated Diphenyl Ethers Quinone Induces NCOA4-Mediated Ferritinophagy Through Selectively Autophagic Degradation of Ferritin, Chemical Research in Toxicology, 2019, 32, 2509−2516
44. Bingwei Yang, Yawen Wang, Qi Qin, Xiaomin Xia, Zixuan Liu, Erqun Song, Yang Song*, Polychlorinated Biphenyl Quinone Promotes Macrophage-Derived Foam Cell Formation, Chemical Research in Toxicology, 2019, 32, 2422−2432
45. Pan Zhang, Dan He, Erqun Song, Mingdong Jiang*, Yang Song*, Celecoxib Enhances the Sensitivity of Non-Small-Cell Lung Cancer Cells to Radiation-Induced Apoptosis Through Downregulation of the Akt/mTOR Signaling Pathway and COX-2 Expression, PLoS One, 2019, 14, e0223760
46. Wenjing Dong, Qiushuang Zhu, Bingwei Yang, Qi Qin, Yawen Wang, Xiaomin Xia, Xiaokang Zhu, Zixuan Liu, Erqun Song, Yang Song*, Polychlorinated Biphenyl Quinone Induces Caspase 1-Mediated Pyroptosis through Induction of Pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD Signal Axis. Chemical Research in Toxicology, 2019, 32, 1051-1057
47. Qiong Shi, Yawen Wang, Wenjing Dong, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells, Toxicology Letters, 2019, 306, 25-34
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