简历：

　　教育经历

　　1999/9–2002/7，中国科学院生态环境研究中心，环境科学，博士，导师: 徐晓白

　　1996/9–1999/7, 协和医科大学, 医学微生物, 硕士, 导师: 季阳

　　1991/9–1995/7, 河北大学, 环境生物学, 学士, 导师: 康现江

　　工作经历

　　2013/12-至今, 中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 研究员，博导

　　2006/7-2013/12，中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 副研，硕导

　　2004/10-2006/6，中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 助研

　　1995/10-1996/8, 河北省保定市环境保护局, 监测站, 科员

　　2002/7-2004/9, 中国科学院生物物理研究所, 博士后, 合作导师: 杨福愉

　　社会任职：

　　全国危险化学品管理标准化技术委员会化学品毒性检测分技术委员会委员

　　中国环境科学学会化学品环境风险防控专业委员会常务委员

　　承担科研项目：

　　1. 国家自然科学基金面上项目，双酚类物质对脊椎动物肠发育和吸收功能的影响和机制，2021/01-2024/12，63万元，在研，主持。

　　2. 国家重点研发计划项目，高灵敏环境持久性有毒污染物感知与识别生物系统子课题，2019/07-2024/06，163万元，在研，主持。

　　3. 国家重点研发计划项目课题，2017YFF0211203，化学品水生毒性测试新物种和快速分级技术研究，2017/07-2021/12，190万元，在研，主持。

　　4. 中国科学院先导科技专项《典型污染物的环境暴露与健康危害机制》子课题，XDB14040102，甲状腺激素信号介导的化学污染物脑发育毒性研究，2014/7-2019/7，475万元，结题，主持。

　　5. 中国科学院前沿科学重点研究项目课题，QYZDJ-SSW-DQC020-03，PBDEs对非洲爪蟾的生殖发育毒性及其机制，2017/01-2021/12，75万元，在研，主持。

　　6. 国家自然科学基金面上项目，21876196，双酚类化合物的神经发育毒性及多信号介导的分子机制，2019/01-2022/12，75万元，在研，主持。

　　7. 国家自然科学基金面上项目，21677166，环境雌激素诱导两栖动物雌性化的分子机制研究，2017/01-2020/12，70万元，结题，主持。

　　获奖及荣誉：

　　2013年度中国科学院杰出科技成就奖（集体奖）。

　　代表论著：

1.       Yuan-Yuan Li, Jin-Bo Li, Yan-Ping Shen, Yi-Ming Xiong, Xing-Hong Li, Zhan-Fen Qin* 2021 Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis. Aquatic Toxicology 232, 105760.

2.       Yue Niu, Min Zhu, Meng-Qi Dong, Jin-Bo Li, Yuan-Yuan Li, Yi-Ming Xiong, Peng-Yan Liu, Zhan-Fen Qin*. Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis. Aquatic Toxicology. 2021, 237,105902.

3.       Min Zhu, Yuan-Yuan Li, Yue Niu, Jin-Bo Li, Zhan-Fen Qin*. Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: A novel signaling by which bisphenols disrupt vertebrate development. Environmental Pollution, 2020, 263 (Pt B): 114443.

4.       Man Cai, Yuan-Yuan Li, Min Zhu, Jin-Bo Li, Zhan-Fen Qin*. Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization. Environmental Pollution, 2020, 260: 113980.

5.       Min Zhu, Yue Niu, Yuan-Yuan Li, Meng-Qi Dong, Jin-Bo Li, Ran Zeng, Zhan-Fen Qin*. Low concentrations of tetrabromobisphenol A disrupt Notch signaling and intestinal development in in vitro and in vivo models. Chemical Research in Toxicology. 2020, 33: 1418-1427.

6.       Jin-Bo Li, Yuan-Yuan Li, Yan-Ping Shen, Min Zhu, Xing-Hong Li, Zhan-Fen Qin*. 2,2',4,4'-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis). Aquatic Toxicology. 2020, 221: 105441.

7.       Yan-Ping Shen, Yuan-Yuan Li, Min Zhu, Jin-Bo Li, Zhan-Fen Qin*. Transcriptional changes caused by estrogenic endocrine disrupting chemicals in gonad-mesonephros complexes of genetic male Xenopus laevis: Multiple biomarkers for early detection of testis differentiation disruption. Science of the Total Environment. 2020, 726: 138522.

8.       Yuan-Yuan Li, Yan-Ping Shen, Jin-Bo Li, Man Cai, Zhan-Fen Qin*. Transcriptomic analysis identifies early cellular and molecular events by which estrogen disrupts testis differentiation and causes feminization in Xenopus laevis. Aquatic Toxicology. 2020, 226: 105557.

9.       Yuan-Yuan Li, Jin-Bo Li, Man Cai, Zhan-Fen Qin* Development of testis cords and the formation of efferent ducts in Xenopus laevis: differences and similarities with other vertebrates. Sexual Development, DOI: 10.1159/000513416

10.     Min Zhu, Xiao-Ying Chen, Yuan-Yuan L, Nuo-Ya Yin, Francesco Faiola, Zhan-Fen Qin* and Wu-Ji Wei*. Bisphenol F disrupts thyroid hormone signaling and postembryonic development in Xenopus laevis. Environmental Science & Technology, 2018, 52(3): 1602-1611.

11.     Yuan-Yuan Li, Tan Meng, Kun Gao, Zhan-Fen Qin*. Gonadal differentiation and its sensitivity to androgens during development of Pelophylax nigromaculatus. Aquatic Toxicology, 2018, 202: 188-195.

12.     Yin-Feng Zhang, Xiao-Min Re, Yuan-Yuan Li, Xiao-Fang Yao, Chuan-Hai Li, Zhan-Fen Qin*, Liang-Hong Guo. Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo. Environmental Pollution, 2018, 237: 1072-1079.

13.     Peng-Yan Liu, Tan Meng, Yuan-Yuan Li, Man Cai, Xing-Hong Li, Juan Chen, Zhanfen Qin*. Tetrabromoethylcyclohexane affects gonadal differentiation and development in the frog Pelophylax nigromaculatus. Aquatic Toxicology, 2017, 192: 40-47.

14.     Yuan-Yuan Li, Juan Chen, Zhan-Fen Qin*. Determining the optimal developmental stages of Xenopus laevis forinitiating exposures to chemicals for sensitively detecting their feminizing effects on gonadal differentiation. Aquatic Toxicology, 2016, 179: 134–142.

15.     Ya-Xian Zhao, Yuan-Yuan Li, Xiao-Fei Qin, Qin-Qin Lou, Zhan-Fen Qin*. Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site. Environmental Pollution, 2016, 218: 1334-1341.

16.     Yuan-Yuan Li, Wei Xu, Xiao-Ran Chen, Qin-Qin Lou, Wu-Ji Wei, Zhan-Fen Qin*. Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus. Aquatic Toxicology, 2015, 58: 230–237.

17.     Xiao-Min Ren, Yin-Feng Zhang, Liang-Hong Guo*, Zhan-Fen Qin*, Qi-Yan Lv, Lian-Ying Zhang. Structure-activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor. Archives of Toxicology, 2015, 89:233–242.

18.     Wei Xu, Yuan-Yuan Li, Qin-Qin Lou, Xiao-Ran Chen, Zhan-Fen Qin*, Wu-Ji Wei*. Low concentrations of dihydrotestosterone induce female-to-male sex reversal in the frog Pelophylax nigromaculatus. Environmental Toxicology and Chemistry, 2015, 34(10): 2370-2377.

19.     Yin-Feng Zhang, Wei Xu, Qin-Qin Lou, Yuan-Yuan Li, Ya-Xian Zhao, Wu-Ji Wei, Zhan-Fen Qin*, Hui-Li Wang*, Jian-Zhong Li. Tetrabromobisphenol A disrupts vertebrate development via thyroid hormone signaling pathway in a developmental stage-dependent Manner. Environmental Science & Technology, 2014, 48(14): 8227–8234.