简历：

　　教育经历

　　2000/08–2006/03， 美国加州大学河滨分校 生物化学与分子生物学， 博士， 导师：Ernest Martinez

　　1989/09–1998/10， 意大利罗马大学 工业化学， 学士/硕士， 导师：Walter Marconi

　　工作经历

　　2014/03-至今，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，研究员

　　2010/07-2014/02，美国西奈山伊坎医学院，布朗克家族干细胞研究所，博士后，合作导师：Jianlong Wang

　　2006/03-2010/06，美国加州大学河滨分校，生物化学与分子生物学，博士后，合作导师：Ernest Martinez

　　承担科研项目：

　　1.国家自然科学基金面上项目，21876197，基于人胚胎干细胞胰腺分化模型研究全氟类化合物与糖尿病发病的相关性，2019/01-2022/12，65万元，在研，主持

　　2.中国科学院前沿科学重点研究项目，QYZDJ-SSW-DQC017，环境小分子与表观遗传的交互作用，2017/01-2021/12，300万元，在研，参加

　　3.国家自然科学基金面上项目，21577166，利用多能干细胞研究环境污染物的健康效应及风险评估，2016/01-2019/12，87.68万元，在研，主持

　　4.中科院人才计划，29人字[2015]30号，中科院2015“百人计划"A类择优支持-Francesco Faiola，2015/01-2018/12，260万元，结题，主持

　　5.知识创新工程重大项目，292015VBC062，2015年院“国际访问学者”，2014/09-2016/08，结题，主持

　　6.中科院战略性先导科技专项（B类），XDB14040300，典型污染物诱导干细胞癌变的机理，2014/07-2019/06，1482.1万元，在研，主持

　　7.中科院生态环境研究中心人才计划，121311ZXPP2014004，“引进人才”匹配经费， 2014/01-2017/12，70万元，结题，主持

　　获奖及荣誉：

　　1.2015 中科院“百人计划”择优支持（A类）

　　2.2015 国科大特聘岗位教授

　　代表论著：

1.      Shengxian Liang, Nuoya Yin, Francesco Faiola*. Human pluripotent stem cells as tools for predicting developmental neural toxicity of chemicals: strategies, applications and challenges. Stem Cells and Development. 2019, doi: 10.1089/scd.2019.0007.

2.      Shaojun Liang, Hui Zhou, Nuoya Yin, Yuanping Lu, Francesco Faiola*. Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity. Journal of Hazardous Materials. 2019, 376, 223-232.

3.      Nuoya Yin, Xiaoxing Liang, Shengxian Liang, Shaojun Liang, Renjun Yang, Bowen Hu, Zhanwen Cheng, Shuyu Liu, Hengzhi Dong, Sijin Liu, Francesco Faiola*. Embryonic stem cell- and transcriptomics- based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities. Ecotoxicology and Environmental Safety. 2019, 176, 330-338.

4.      Yang Zhang#, Nuoya Yin#, Shengxian Liang, Su Shen, Dandan Li, Francesco Faiola*. 5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway. International Journal of Clinical and Experimental Medicine. 2019, 12(3), 2334-2343.

5.      Shengxian Liang, Shaojun Liang, Nuoya Yin, Francesco Faiola*. Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations. Ecotoxicology Environmental Safety. 2019, 174, 353-362.

6.      Shuyu Liu, Renjun Yang, Nuoya Yin, Yuan-Liang Wang, Francesco Faiola*. Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis. Ecotoxicology and Environmental Safety. 2019, 169, 564-572.

7.      Hengzhi Dong, Xinglei Yao, Shuyu Liu, Nuoya Yin, Francesco Faiola*. Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis. Ecotoxicology and Environmental Safety. 2018, 164, 448-454.

8.      Nuoya Yin#, Bowen Hu#, Renjun Yang, Shaojun Liang, Shengxian Liang, Francesco Faiola*. Assessment of the developmental neurotoxicity of silver nanoparticles and silver ions with mouse embryonic stem cells in vitro. Journal of Interdisciplinary Nanomedicine. 2018, 3(3), 133-145.

9.      Shuyu Liu, Nuoya Yin, Francesco Faiola*. PFOA and PFOS Disrupt the Generation of Human Pancreatic Progenitor Cells. Environmental Science & Technology Letters. 2018, 5(5), 237-242.

10.    Nuoya Yin#, Renjun Yang#, Shaojun Liang, Shengxian Liang, Bowen Hu, Ting Ruan, Francesco Faiola*. Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an in vitro mouse stem cell differentiation model. Chemosphere. 2018, 204, 109-118.

11.    Nuoya Yin#, Shaojun Liang#, Shengxian Liang, Renjun Yang, Bowen Hu, Zhanfen Qin, Aifeng Liu, Francesco Faiola*. TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways. Environmental Science & Technology. 2018, 52 (9), 5459-5468.

12.    Nuoya Yin#, Shengxian Liang#, Shaojun Liang, Bowen Hu, Renjun Yang, Qunfang Zhou, Guibin Jiang, Francesco Faiola*. DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development. Environmental Pollution. 2018, 236, 21-32.

13.    Francesco Faiola#,* Nuoya Yin#, Miguel Fidalgo, Xin Huang, Arven Saunders, Junjun Ding, Diana Guallar, Baoyen Dang, and Jianlong Wang*. NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression. Stem Cell Reports. 2017, 9 (3), 913-926.

14.    Shuyu Liu, Nuoya Yin, Francesco Faiola*. Prospects and Frontiers of Stem Cell Toxicology. Stem Cells & Development. 2017, 26 (21), 1528-1539.

15.    Xinglei Yao, Nuoya Yin, Francesco Faiola*. Stem cell toxicology: a powerful tool to assess pollution effects on human health. National Science Review. 2016, 3(4), 430-450.

16.    Nuoya Yin, Xinglei Yao, Zhanfen Qin, Yuan-Liang Wang, Francesco Faiola*. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells. Journal of Environmental Sciences. 2015, 36, 181-187.

17.    Francesco Faiola*, Nuoya Yin, Xinglei Yao, Guibin Jiang. The Rise of Stem Cell Toxicology. Environmental Science & Technology. 2015, 49 (10), 5847-5848.

18.    Nuoya Yin, Xinglei Yao, Qunfang Zhou, Francesco Faiola*, GuibinJiang. Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats. Biochemical and Biophysical Research Communications. 2015, 458 (2), 405-410.

19.    Francesco Faiola, Arven Saunders, Baoyen Dang, Jianlong Wang*. An improved in vivo biotinylation strategy combined with Flag and antibody based approaches for affinity purification of protein complexes in mouse embryonic stem cells. Methods in Molecular Biology. 2014, 1177, 135-149.

20.    Diana Guallar, Xianju Bi, Jose Angel Pardavila, Xin Huang, Carmen Saenz, Xianle Shi, Hongwei Zhou, Francesco Faiola, Junjun Ding, Phensinee Haruehanroengra, Fan Yang, Dan Li, Carlos Sanchez-Priego, Arven Saunders, Feng Pan, Victor Julian Valdes, Kevin Kelley, Miguel G. Blanco, Lingyi Chen, Huayan Wang, Jia Sheng, Mingjiang Xu, Miguel Fidalgo, Xiaohua Shen, Jianlong Wang*. RNA-dependent chromatin targeting of TET2 for endogenous retrovirus cpntrol in pluripotent stem cells. Nature Genetics. 2018, 50(3), 443-451.

21.    Jia Wang, Xingui Wu, Chao Wei, Xin Huang, Qian Ma, Xiaona Huang, Francesco Faiola, Diana Guallar, Miguel Fidalgo, Tingyuan Huang, Di Peng, Li Chen, Haopeng Yu, Xingyu Li, Junyi Sun, Xinyi Liu, Xiaoxia Cai, Xiao Chen, Ling Wang, Jian Ren, Jianlong Wang*, Junjun Ding*. YY1 positively regulates transcription by targeting promoters and super-enhancers through the BAF complex in embryonic stem cells. Stem Cell Reports. 2018, 10(4), 1324-1339.

22.    Arven Saunders, Dan Li, Francesco Faiola, Xin Huang, Miguel Fidalgo, Diana Guallar, Junjun Ding, Fan Yang, Yang Xu, Hongwei Zhou, Jianlong Wang*. Context-dependent functions of NANOG phosphorylation in pluripotency and reprogramming. Stem Cell Reports. 2017, 8(5), 1115-1123.

23.    Arven Saunders, Xin Huang, Miguel Fidalgo, Michael H. Reimer Jr., Francesco Faiola, Junjun Ding, Carlos Sánchez-Priego, Diana Guallar, Carmen Sáenz, Dan Li, Jianlong Wang*. The SIN3A/HDAC corepressor complex functionally cooperates with NANOG to promote pluripotency. Cell Reports. 2017, 18, 1713-1726.

24.    Li Wan#, Xinglei Yao#, Francesco Faiola, Bojun Liu, Tianyuan Zhang, Yasuhiko Tabata, Hiroyuki Mizuguchi, Shinsaku Nakagawa, Jian-Qing Gao*, Robert Chunhua Zhao*. Coating with spermine-pullan polymer enhances adenoviral transduction of mesenchymal stem cells. International Journal of Nanomedicine. 2016, 11, 6763-6769.

25.    Junjun Ding, Xin Huang, Ningyi Shao, Hongwei Zhou, Dung-Fang Lee, Francesco Faiola, Miguel Fidalgo, Diana Guallar, Arven Saunders, Pavel V. Shliaha, Hailong Wang, Avinash Waghray, Dmitri Papatsenko, Carlos Sánchez-Priego, Dan Li, Ye Yuan, Ihor R. Lemischka, Li Shen, Kevin Kelley, Haiteng Deng, Xiaohua Shen, Jianlong Wang*. Tex10 coordinates epigenetic control of super-enhancer activity in pluripotency and reprogramming. Cell Stem Cell. 2015, 16, 653-668.

26.    Julian A. Gingold, Miguel Fidalgo, Diana Guallar, Zerlina Lau, Zhen Sun, Hongwei Zhou, Francesco Faiola, Xin Huang, Dung-Fang Lee, Avinash Waghray, Christoph Schaniel, Dan P. Felsenfeld, Ihor R. Lemischka*, Jianlong Wang*. A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Molecular Cell. 2014, 56(1), 140-152.

27.    Na Zhang, Wataru Ichikawa, Francesco Faiola, Szu-Ying Lo, Xiaohui Liu, Ernest Martinez*. MYC interacts with the STAGA complex via multivalent contacts with the GCN5 and TRRAP subunits. Biochimica et Biophysica Acta. 2014, 1839(5), 395-405.

28.    Kai Lee Yap, Polina Sysa-Shah, Brad Bolon, Ren-Chin Wu, Min Gao, Alice L. Herlinger, Fengying Wang, Francesco Faiola, David Huso, Kathleen Gabrielson, Tian-Li Wang, Jianlong Wang*, Ie-Ming Shih*. Loss of NAC1 Expression Is Associated with Defective Bony Patterning in the Murine Vertebral Axis. PloS One. 2013, 8(7), e69099.

29.    Arven Saunders, Francesco Faiola, Jianlong Wang*. Concise Review: Pursuing Self‐Renewal and Pluripotency with the Stem Cell Factor Nanog. Stem Cells. 2013, 31(7), 1227-1236.

30.    Yael Costa#, Junjun Ding#, Thorold W. Theunissen#, Francesco Faiola#, Timothy A. Hore, Pavel V. Shliaha, Miguel Fidalgo, Arven Saunders, Moyra Lawrence, Sabine Dietmann, Satyabrata Das, Dana N. Levasseur, Zhe Li, Mingjiang Xu, Wolf Reik, José C. R. Silva*, Jianlong Wang*. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013, 495(7441), 370-374.

31.    Miguel Fidalgo, Francesco Faiola, Carlos-Filipe Pereira, Junjun Ding, Arven Saunders, Julian Gingold, Christoph Schaniel, Ihor R. Lemischka, José C. R. Silva, Jianlong Wang*. Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proceeding of the National Academy of Sciences of the United States of America. 2012, 109(40), 16202-16207.

32.    Yuan-Liang Wang, Francesco Faiola, Ernest Martinez*. Purification of multiprotein histone acetyltransferase complexes. Methods in Molecular Biology. 2012, 809, 427-443.

33.    Junjun Ding, Huilei Xu, Francesco Faiola, Avi Ma'ayan, Jianlong Wang*. Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Research. 2012, 22(1), 155-167.

34.    Takuya Fukazawa*, Yutaka Maeda, Junji Matsuoka, Tomoki Yamatsuji, Kaoru Shigemitsu, Ichiro Morita, Francesco Faiola, Mary L. Durbin, Laura Soucek, Yoshio Naomoto. Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc. Anticancer Research. 2010, 30(10), 4193-4200.

35.    Yuan-Liang Wang, Francesco Faiola, Muyu Xu, Songqin Pan, Ernest Martinez*. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Journal of Biological Chemistry. 2008, 283(49), 33808-33815.

36.    Xiaohui Liu, Marina Vorontchikhina, Yuan-Liang Wang, Francesco Faiola, Ernest Martinez*. STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Molecular and Cellular Biology. 2008, 28(1), 108-121.

37.    Francesco Faiola#, Yi-Ting Wu#, Songqin Pan, Kangling Zhang, Anthony Farina, Ernest Martinez*. Max is acetylated by p300 at several nuclear localization residues. Biochemical Journal. 2007, 403(3), 397-407.

38.    Francesco Faiola#, Xiaohui Liu#, Szuying Lo, Songqin Pan, Kangling Zhang, Elena Lymar, Anthony Farina, Ernest Martinez*. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Molecular and Cellular Biology. 2005, 25(23), 10220-10234.

39.    Kangling Zhang, Francesco Faiola, Ernest Martinez*. Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochemical and Biophysical Research Communications. 2005, 336(1), 274-280.

40.    Anthony Farina, Francesco Faiola, Ernest Martinez*. Reconstitution of an E box-binding Myc:Max complex with recombinant full-length proteins expressed in Escherichia coli. Protein Expression and Purification. 2004, 34(2), 215-222.

41.    Walter Marconi*, Francesco Faiola, Antonella Piozzi. Catalytic activity of immobilized fumarase. Journal of Molecular Catalysis B- Enzymatic. 2001, 15(1-3), 93-99.