简历：

　　朱本占，中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室研究员，中国科学院大学教授，博士生导师，中国科学院生态环境研究中心-香港浸会大学环境科学联合研究所所长。1989年获中科院兰州化物所硕士学位，1999年获以色列希伯莱大学－哈达萨医学院(Hebrew University in Jerusalem - Hadassah Medical School)生物化学博士学位。1999年7月在美国Linus Pauling Institute进行博士后研究，2002年7月升为高级研究助教授。2006年入选中科院“百人计划”并在终期评估中被评为“优秀”, 2009 年获国家基金委“杰出青年基金”支持并在终期评估中被评为“优秀”。 主要从事的研究方向为： 自由基特别是羟基自由基、活性中间体、具有氧化还原活性的过渡金属离子/络合物与天然抗氧化剂化学生物学；新型自由基/活性中间体形成机理和DNA损伤等生物学效应；正常生理条件下即可发生的系列重排反应机理；“阴·阳离子对”的形成与活细胞核“DNA光开关”、“DNA光-电融合探针”及光动力抗癌药物；复合有机和无机环境污染物协同毒性/作用机理等；为典型的多学科交叉领域研究。其系统性研究成果丰富和发展了经典羟基自由基产生理论，在自由基产生机制方面有重要突破，推动并引领了污染物自由基化学的发展。代表性研究成果在国际权威学术期刊《美国科学院院刊》(PNAS)以难度最大的自由投稿方式连续发表五篇论文，被写入《Free Radicals in Biology and Medicine》经典教科书。代表性研究成果多次被Science等期刊作专栏或亮点/封面介绍, 入选中科院“十二五”重大科技成果及标志性进展（为资环领域唯一入选项目）。由于在自由基化学与毒理学方面的影响，应邀在美国著名的“Gordon研究会议”作50分钟大会报告，在“第14届国际自由基研究大会”作邀请报告，在“香山会议”、“双清论坛”等重要学术会议作专题报告；应邀担任美国化学会著名毒理学期刊Chem. Res. Toxicol.等多个学术期刊的编委或特约/专刊编辑；当选为中国环境诱变剂学会“活性氧生物效应专业委员会”副主任，中国生物物理学会“生物与医学自由基分会” 理事；作为学术带头人，2013年获国家基金委“创新群体”基金支持，2016年被评为“优秀”并获连续资助；荣获中科院“杰出科技成就奖”，顺磁共振发展奖励基金“杰出贡献奖”。

　　社会任职：

　　1. Chem. Res. Toxicol.《化学毒理学研究》编委，“中国特刊”特邀编辑

　　2. 《科学通报》编委和特约编辑

　　3. 《环境化学》编委

　　4. 中国生物物理学会“生物与医学自由基专业委员会”理事

　　5. 中国环境诱变剂学会“活性氧生物效应专业委员会”副主任

　　6. 中国科学院生态环境研究中心—浸会大学环境科学联合研究所所长

　　承担科研项目：

　　1. 国家自然科学基金重点项目，21836005，新型手性多环芳胺-DNA加合物的自由基形成机理和生物学效应，2019/01-2023/12，316万元，在研，主持

　　2. 国家自然科学基金创新群体项目，21621064，持久性有毒污染物的环境过程与毒理效应，2017/01-2019/12，525万，在研，主持

　　3. 中国科学院战略性先导科技专项(B类) XDB14030100 典型污染物的环境暴露与健康危害机制项目三课题1污染物引发的自由基产生与生物损伤，2014/07-2019/06， 860万，在研，主持

　　4. 国家自然科学基金面上项目，21477139,高级氧化过程中卤代芳烃产生化学发光的分子机制及应用研究 2015/01-2018/12, 95万，结题，主持

　　5. 国家自然科学基金创新群体项目，21321004，持久性有毒污染物的环境过程与毒理效应，2014/01-2016/12，600万，结题，主持

　　6. 国家自然科学基金重点项目，21237005，有机农药与含铜、锌无机农药的协同毒性作用机理研究，2013/01-2017/12，300万，结题，主持

　　7. 国家杰出青年科学基金项目，20925724， 环境化学，2010/01-2013/12，200万，结题，主持

　　8. 国家自然科学基金面上项目，20877081，有机与无机木材保护剂协同毒性作用机理的研究，2009/01-2011/12，30万，结题，主持

　　9. 973项目，2008CB418106，大中型浅水湖泊蓝藻水华暴发机理研究，2008/01-2012/12，50万，结题，第六课题负责人

　　10. 国家自然科学基金面上项目，20777080，不依赖金属离子存在型羟基自由基的生成及DNA损伤机理的研究，2008/01-2010/12，30万，结题，主持

　　11. 国家自然科学基金创新群体项目，20921063，持久性有毒污染物的形态、环境过程与毒理效应，2008/01-2009/12，55万，结题，参加

　　12. 中国科学院“百人计划”项目，自由基化学，2006/06-2010/05，200万，结题，主持

　　获奖及荣誉：

　　1. 2018年，获徐元植顺磁共振发展奖励基金杰出贡献奖

　　2. 2013年，获国家基金委“创新群体”基金支持，2016年被评为“优秀”并获连续资助

　　3. 2013年，获中国科学院杰出科技成就奖

　　4. 2009 年，获国家基金委“杰出青年基金”支持并在终期（2014年）考核中被评为“优秀”

　　5. 2006年，获中科院“百人计划”支持并在终期评估（2011年）中被评为“优秀”

　　代表论著：

1.      Zhu B.Z., Zhao H.T., Kalyanaraman B. Liu J., Shan G.Q., Du Y.G. and Frei B. (2007) Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 3698-3702.

2.      Zhu B.Z., Kalyanaraman B. and Jiang G.B. (2007) Molecular Mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 17575-17578.

3.      Zhu B.Z., Shan G.Q., Huang C.H. and Kalyanaraman B. (2009) Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical. Proc. Natl. Acad. Sci. USA 106: 11466-11471.

4.      Zhu B.Z., Zhu J.G., Kalyanaraman B., Mao L. and Shan G.Q. (2010) Detoxifying polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement. Proc. Natl. Acad. Sci. USA 107: 20286-20290.

5.      Zhu B.Z., Mao L., Huang C.H., Qin H., Fan R.M., Kalyanaraman B., Zhu J.G. (2012) Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H₂O₂. Proc. Natl. Acad. Sci. USA 109: 16046-16051.

6.      Sheng Z.G., Zhu B.Z. (2011) Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G-protein-coupled receptor 30 and estrogen receptor-α. Environ. Health Perspect. 119: 1775-1780.

7.      Chao XJ, Tang M, Huang R, Huang CH, Shao J, Yan ZY, Zhu B.Z. (2019) Targeted Live-Cell Nuclear Delivery of the DNA ‘Light-switching’ Ru(II) Complex via Ion-Pairing with Chlorophenolate Counter-Anions: The Critical Role of Binding Stability and Lipophilicity of the Ion-Pairing Complexes. Nucleic Acids Res. doi: 10.1093/nar/gkz152

8.      Xu D, Huang CH, Xie LN, Shao B, Mao L, Shao J, Kalyanaraman B, Zhu BZ (2019) Mechanism of Unprecedented Hydroxyl Radical Production and Site-Specific Oxidative DNA Damage by Photo Activation of the Classic Arylhydroxamic Acid Carcinogens. Carcinogenesis doi: 10.1093/carcin/bgz021

9.      Sheng ZG, Shen C, Fan RM, Chao, Liu YX, Zhu BZ (2019) The Critical Role of X Chromosome-linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-phenanthroline Complex in Normal and Cancer Liver Cells. Toxicol. Sci., 168: 339-348.

10.    Xie LN, Shao J; Huang CH; Li F; Xu D; i Qin L; Kalyanaraman B, Zhu BZ (2019) An Unusual Double Radical Homolysis Mechanism for the Unexpected Activation of the Aldoxime Nerve-Agent Antidotes by Polyhalogenated Quinoid Carcinogens under Normal Physiological Conditions. Free Radic. Biol. Med. 130: 1-7.

11.    Sheng ZG, Wang C, Ren FR, Liu YX, Zhu BZ  (2019) The Molecular Mechanism of Endocrine-Disruptive Effects Induced by Bisphenol A: The Role of Transmembrane G-Protein Estrogen Receptor 1 and Integrin αvβ3. J. Environ. Sci. 75: 1-13. 

12.    Xie LN, Huang CH, Xu D, Li F, Zhu JG, Shen C, Shao B, Gao HY, Kalyanaraman B, Zhu BZ. (2017) Unusual double Beckmann fragmentation reaction under physiological conditions. J. Org. Chem. 82: 13084-13092.

13.    Gao H.Y., Mao L, Li F, Xie LN, Huang CH, Shao J, Shao B, Kalyanaraman B, and Zhu BZ (2017) Mechanism of intrinsic chemiluminescence production from the degradation of persistent chlorinated phenols by Fenton system: A structure-activity relationship study and the critical role of quinoid and semiquinone radical intermediates. Environ. Sci. Technol. 51: 2934-2943.

14.    Shao B., Mao L, Qu N, Wang YF, Gao HY, Li F, Qin L, Shao J, Huang CH, Xu D, Xie LN, Shen C, Zhou X and Zhu BZ (2017) Mechanism of synergistic DNA damage induced by the hydroquinone metabolite of brominated phenolic environmental pollutants and Cu(II): Formation of DNA-Cu complex and site-specific production of hydroxyl radicals Free Radic. Biol. Med. 104: 54-63.

15.    Li F, Huang CH, Xie LN, Qu N, Shao J, Shao B and Zhu BZ (2016) An exceptionally facile two-step structural isomerization and detoxication via a water-assisted double Lossen rearrangement. Sci. Rep. 6: 39207. doi: 10.1038/srep39207.

16.    Mao, L., Huang, C.H., Gao, H.Y., Kalyanaraman, B., Zhu, B.Z. (2015) Intrinsic chemiluminescence generation during advanced oxidation of persistent halogenated aromatic carcinogens. Environ. Sci. Technol. 49: 7940-7947.

17.    Huang, C.H.; Ren, F.R.; Shan, G.Q.; Qin, H.; Mao, L.; Zhu, B.Z. (2015) Molecular mechanism of metal-independent decomposition of organic hydroperoxides by the halogenated quinoid carcinogens and the potential biological implications. Chem. Res. Toxicol., 28, 831-837. (Cover story)

18.    Zhu B.Z., Hollenberg PF (2015) Chemical toxicology in China: A special issue. Chem. Res. Toxicol. 28: 279-280. (Guest Editor’s Editorial)

19.   Shan GQ, Yu A, Zhao CF, Huang CH, Zhu LY, Zhu B.Z. (2015) A combined experimental and computational investigation on the unusual molecular mechanism of the Lossen rearrangement reaction activated by carcinogenic halogenated quinones. J. Org. Chem. 80: 180-189.

20.   Li Y, Huang CH, Liu YX, Mao L, Zhu B.Z. (2014) Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure. Chem. Eur. J. 20: 13028-13033.

21.   Zhao B., et al., (2014) Redox-active quinones induce genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res. 42: 1593-1605.

22.   Qin H, Huang CH, Shan GQ, Mao L, Kalyanaraman B, Zhu B.Z. (2013) Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic. Biol. Med. 63: 459-466.

23.   Shao J, Huang CH, Kalyanaraman B, Zhu B.Z. (2013) Potent methyl oxidation of 5-methyl-2’-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic. Biol. Med. 60: 177-182.

24.   Yin R, Zhang D, Song Y, Zhu B.Z., Wang H (2013) Potent DNA damage by polyhalogenated quinoid carcinogens and H₂O₂ via a metal-independent and intercalation-enhanced oxidation mechanism. Sci. Rep. 3: 1269; doi: 10.1038/srep01269

25.   Huang CH, Shan GQ, Kalyanaraman B. Zhu B.Z. (2013) The first purification and unequivocal characterization of the unusual carbon-centered quinone ketoxy radical adduct. Chem. Commun. 49: 6436-6439.

26.   Sheng ZG, Li Y, Fan RM, Chao XJ, Zhu B.Z. (2013) Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex. Toxicol. Appl. Pharmacol. 266: 335-344.

27.   Zhu B.Z., Zhu J.G., Fan R.M., Mao L. (2011) Metal-Independent Pathways of Chlorinated Phenol/Quinone Toxicity. Advances in Molecular Toxicology (Ed. J. C. Fishbein) Vol. 5, pp 1-43. (Invited Book Chapter)

28.   Zhu B.Z., Mao L., Fan R.M., Zhu J.G. Zhang Y.N., Wang J., Kalyanaraman B., Frei B. (2011) Ergothioneine prevents copper-induced oxidative damage to DNA and protein by formation of a redox-inactive ergothioneine-copper complex. Chem. Res. Toxicol. 24: 30-34.

29.   Zhu B.Z. and Shan G.Q. (2009) Potential mechanism for pentachlorophenol-induced carcinogenicity: A novel mechanism for metal-independent production of hydroxyl radicals. Chem. Res. Toxicol. 22: 969-977. (Invited Perspective)

30.   Barbouti A., Doulias P.T., Zhu B.Z., Frei B. and Galaris D. (2005) Mechanism of protection by tropolones against hydrogen peroxide-induced DNA damage and apoptosis. Free Radic. Res. 39: 125-135.

31.   Zhu B.Z. and Frei B. (2002) Biochemical and physiological interactions of vitamin C and iron: Pro- or anti-oxidant? In: The Antioxidant Vitamins C and E. (Packer, L. Traber, M. G. Kraemer, K. and Frei, B. Eds.), AOCS Press, Champaign, IL, pp32-49.

32.   Zhu B.Z., Carr A.C. and Frei B. (2002) Pyrrolidine dithiocarbamate (PDTC) is a potent antioxidant against hypochlorous acid-mediated protein oxidation. FEBS Lett. 532: 80-84.

33.   Zhu B.Z. Antholine W.E. and Frei B. (2002) Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex. Free Radic. Biol. Med. 32: 1333-1338.

34.   Zhu B.Z., Zhao H.T., Kalyanaraman B. and Frei B. (2002) Metal-independent production of hydroxyl radicals by chlorinated quinones and hydrogen peroxide: an ESR spin-trapping study, Free Radic. Biol. Med. 32: 465-473.

35.   Barbouti A., Doulias P.T., Zhu B.Z., Frei, B. and Galaris D. (2001) Intracellular iron, but not copper, plays a critical role in hydrogen peroxide induced DNA damage. Free Radic. Biol. Med. 31: 490-498.

36.   Zhu B.Z. and Chevion M. (2000) Mechanism of synergistic toxicity of pentachlorophenol and copper(II)-1,10-phenanthroline complexes: The formation of lipophilic ternary complexes. Chem-Biol. Interaction 129: 249-261.

37.   Carr A.C., Zhu B.Z. and Frei B. (2000) Potential anti-atherogenic mechanisms of ascorbate and a-tocopherol. Circulation Res. 87: 349-354.

38.   Zhu B.Z., Har-El R., Kitrossky N. and Chevion M. (1998) New modes of action of desferrioxamine: Scavenging of semiquinone radical and stimulation of hydrolysis of tetrachlorohydroquinone. Free Radic. Biol. Med. 24: 360-369.