环境化学与生态毒理学国家重点实验室

近期成果

代表论文: #共同第一作者,*通讯作者)

1.        Liu, J.#; Jiang, J.#; Mo, J.#; Liu, D.#; Cao, D.; Wang, H(ailin)*; He, Yufei*; Wang H(ongyang).* Global DNA 5-hydroxymethylcysotine and 5-formylcytosine contents are decreased in the early stage of hepatocellular carcinoma. Hepatology, doi: 10.1002/hep.30146. (IF = 14.079)

2.        Yang, X.#; Yang, Y.#; Sun, B. F.#; Chen, Y. S.#; Xu, J. W.#; Lai, W. Y.#; Li, A.; Wang, X.; Bhattarai, D. P.; Xiao, W.; Sun, H. Y.; Zhu, Q.; Ma, H. L.; Adhikari, S.; Sun, M.; Hao, Y. J.; Zhang, B.; Huang, C. M.; Huang, N.; Jiang, G. B.; Zhao, Y. L.; Wang, H. L.*; Sun, Y. P.*; Yang, Y. G.* 5-methylcytosine promotes mRNA export – NSUN2 as the methyltransferases and ALYREF as an m5C reader. Cell Res. 27:606-625 (2017) (Cover, highlighted). (IF = 15.606)

3.        Zhao, B.#; Zhang, D#.; Li, C.; Yuan, Z.; Zhong, S.; Jiang, G.; Yang, Y. G.; Le, X. C.; Weinfeld, M.; Zhu P.; Wang, H.* ATpase activity tightly regulates RecA nucleofilaments to promote homologous recombination. Cell Discov. 3:16053 (2017).

4.        Zhang, G.#; Huang, H.#; Liu, D.#;, Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J.; Li,C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.*; Chen, D.* N6-methyladenine DNA modification in Drosophila. Cell, 161:893-906 (2015). (Previewed by Cell, Cover, IF = 31.398) (Google citation: 202)

5.        Zhao, C.; Wang, H.*; Zhao, B. L.; Li, C. P.; Yin, R.; Song, M.; Liu, Z.; Jiang, G. B. Boronic acid-mediated polymerase chain reaction for gene- and fragment-specific detection of 5-hydroxymethylcytosine. Nucleic Acids Res., 42: e81 (2014). (IF = 11.561)

6.        Zhao, B. L.#; Yang, Y. #; Wang, X.#; Chong Z.; Yin, R.; Song, S. H.; Zhao, C.; Li, C.; Huang, H.; Sun, B. F. Wu, D.; Jin, K. X. Song, M.; Zhu, B. Z.; Jiang, G.; Danielsen, J. M. R.; Xu, G. L.; Yang, Y. G.*; Wang, H.* Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Res., 42:1593-1605 (2014). (IF = 11.561)

7.        Yin, R.; Mao, S.-Q.; Zhao, B.; Chong, Z.; Yang, Y.; Zhao, C.; Zhang, D.; Huang, H.; Gao, J.; Li, Z,; Jiao, Y.; Li, C.; Liu, S.; Wu, D.; Gu, W.; Yang, Y. G.; Xu, G. L.; Wang, H.* Ascorbic Acid Enhances Tet-mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals. J. Am. Chem. Soc., 135:10396-10403 (2013). (Highlighted by Nature Reviews Genetics) (IF = 14.357) Google citation: 240)

8.        Liu, S.; Zhao, B.; Zhang, D.; Li, C.; Wang, H*. Imaging of Non-uniform Motion of Single DNA Molecules Reveals the Kinetics of Varying-Field Isotachophoresis. J. Am. Chem. Soc., 135:4644-4647 (2013). (IF = 14.357)

9.        Zhang, D. P.; Lu, M.; Wang, H.* Fluorescence anisotropy analysis for mapping aptamer-protein interaction at the single nucleotide level. J. Am. Chem. Soc., 133: 9188-9191 (2011). (IF = 14.357)

10.     Wang, H.; Lu, M.; Tang, M.-S.; Van Houten, B.; Ross, J. B. A.; Weinfeld, M.*; Le, X. C*. DNA wrapping is required for DNA damage recognition in the Escherichia coli DNA nucleotide excision repair pathway. Proc. Natl. Acad. Sci. USA, 106: 12849-12854 (2009).

BOOK and BOOK CHAPTERS:

1.          Wang, H.*; Lu, M.; Dever, B; Shen, S.; Le, X. C. Section 3.15: Affinity capillary electrophoresis in the study of DNA damage, repair, and methylation. Book: Comprehensive sampling and sample preparation. Elsevier Press. 2012)

2.          Lu, M.*; Wang, H.; Geisel, Z.; Le, X. C. Section 3.26: Enzyme digestion for arsenic speciation. Book: Comprehensive sampling and sample preparation. Elsevier Press. 2012

3.          江桂斌,汪海林,戴家银,吕雪飞,邵晶。现代毒理学,译自A Textbook of morden toxicology Text (3rd edition, edited by Enerst Hodgson). 科学出版社。 2011.

 

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