环境化学与生态毒理学国家重点实验室

周群芳

发布时间:2018-07-09  |  【打印】 【关闭

  
姓名:周群芳 [博士生导师]性别:女职称:研究员电话:010-62849334E-mail:zhouqf@rcees.ac.cn组别:环境分析与毒理研究组研究方向:新型污染物的毒理学效应与分子机制招生专业:环境毒理与健康
  

      简历:

  教育经历

  1997/09-2002/06,中国科学院生态环境研究中心 环境化学与生态毒理国家重点实验室 环境科学,博士 导师:江桂斌院士

  1992/09-1997/06,北京医科大学 获学士学位

  工作经历

  2016/01-至今,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,研究员,博士生导师

  2010/08-2013/6,美国哈佛医学院加斯林糖尿病中心,访问学者

  2009/11-2010/7, 美国St Jude Children’s Research Hospital,访问学者

  2005/01-2015/12,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,副研究员,硕士生导师

  2003/01-2003/03,日本国土环境株式会社,访问学者

  2002/07-2004/12,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,助理研究员

  社会任职:

  1. 中国化学会会员

  2. 中国毒理学会分析毒理专业委员会委员

  承担科研项目:

  1. 国家自然科学基金面上项目,21876195,新型有机卤代化合物调控维甲酸受体诱导鱼类胚胎发育毒性效应及分子机制,2019/01-2022/12,65万,在研,主持。

  2. 中国科学院前沿科学重点研究项目,QYZDJ-SSW-DQC017,环境小分子与表观遗传的交互作用,2017/01-2021/12,300万元,在研,参加。

  3. 国家自然科学国际(地区)合作与交流项目,21461142001,新型持久性有机污染物的生殖发育毒性机制与筛选方法研究,2015/01-2019/12,300万元,在研,参加。

  4. 中国科学院重大专项B,14040302,污染物的毒性与健康危害机制,2014/01-2019/06,60万元,在研,子课题主持。

  5. 国家自然科学基金面上项目,21477153,基于血管舒缓素-激肽系统研究纳米银穿透血脑屏障产生神经毒性的分子作用机制,2015/01-2018/12,95万元,结题,主持。

  6. 国家科技部863项目,2009AA06Z407,环境内分泌干扰物筛选与监测技术,2010/06-2013/06,103万元,结题,主持。

  7. 国家自然科学基金面上项目,20977100,基于离体或活体模型的金属纳米颗粒的粒度相关性生物学效应研究, 2010/01-2012/12,34万元,结题,主持。

  8. 国家科技部863项目,2006AA06Z424,环境内分泌干扰物筛选与监测技术,2007/01-2009/12,250万元,结题,主持。

  9. 国家自然科学基金青年基金项目,40503014,筛选有机锡、有机汞污染的海洋双壳类生物指示物及其化学与分子生物学基础研究,2006/01-2008/12,32万元,结题,主持。

  10. 国家自然科学基金重点基金项目,21137002,典型纳米材料的生物毒性效应及调控研究,2012/01-2016/12,60万元,已结题,参加。

  11. 国家科技部973项目,2011CB936001,纳米材料的水处理器件化方法及其应用基础研究,2011/06-2015/06,62.8万元,已结题,参加。

  12. 国家科技部支撑计划,2007BAC27B02,POPs的机体负荷与健康效应评价技术,2008/01-2011/12,170万元,已结题,参加。

  13. 国家科技部水专项,2008ZX07101-006,农业面源污染河流综合整治技术集成与示范工程,2008/09-2010/12,123.5万元,已结题,参加。

  14. 国家科技部创新方法工作专项,2008IM021600,致病菌和环境污染物的快速检测方法技术研究,2008/12-2010/10,30万元,已结题,参加。

  15. 中国科学院知识创新工程重要方向项目,KZCX2-YW-420-21,持久性有毒污染物的健康风险与控制原理,2007/01-2009/12,50万元,已结题,参加。

  16. 国家自然科学基金重点基金项目,20537020,环境纳米污染物和纳米材料在微界面的反应过程及生态环境效应,2006/01-2009/12,25万元,已结题,参加。

  17. 国家自然科学基金重大基金项目,40590392,低纬度地区电子废物处理POPs风险区的地球化学与健康效应,2005/01-2008/12,40万元,已结题,参加。

  

  获奖及荣誉:

  1. 环境保护科学技术二等奖(2017年)

  2. 中国毒理学会全国优秀青年科技奖(2014年)

  3. 中华医学科技奖二等奖(2012年)

  4. 中华医学科技奖三等奖(2009年)

  5. 中国食品科学技术学会科技创新奖-技术进步二等奖(2008年)

  6. 中国分析测试协会科学技术奖(CAIA奖)一等奖(2005年)

  7. 环境保护科学技术奖二等奖(2004年)

  8. 中国科学院院长优秀奖(2002年)

  9. 中国分析测试协会科学技术奖(CAIA奖)一等奖(2001年)

  代表论著:

1.      Xiaoxi Yang, Zhendong Sun, Qian S. Liu, Nuoya Yin, Qunfang Zhou*, Francesco Faiola*, Chunyang Liao, Guibin Jiang. Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo. Toxicology Letters, 2019, 312, 139-147.

2.      Fang Hao, Qian S. Liu, Xi Chen, Xingchen Zhao, Qunfang Zhou*, Chunyang Liao, Guibin Jiang. Exploring the heterogeneity of nanoparticles in their interactions with plasma coagulation factor XII. ACS Nano, 2019, 13(2), 1990-2003.

3.      Xiaoting Jin, Qianchi Ma, Zhendong Sun, Xuezhi Yang, Qunfang Zhou*, Guangbo Qu, Qian Liu, Chunyang Liao, Zhuoyu Li, Guibin Jiang. Airborne fine particles induce hematological effects through regulating the crosstalk of the kallikrein-kinin, complement and coagulation systems. Environmental Science & Technology, 2019, 53(5), 2840-2851.

4.      Qunfang Zhou, Guibin Jiang*. Truncated tetrahedral CdTe QDs act as endonucleases through local ROS induction. Chem, 2018, 4, 2022-2023.

5.      Xiaoxi Yang, Zhendong Sun, Wanyi Wang, Qunfang Zhou*, Guoqing Shi, Fusheng Wei, Guibin Jiang. Developmental toxicity of synthetic phenolic antioxidants to the early life stage of zebrafish. Science of the Total Environment, 2018, 643, 559-568.

6.      Wenting Song, Qian S. Liu, Zhendong Sun, Xiaoxi Yang, Qunfang Zhou*, Guibin Jiang. Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms. Environmental Pollution, 2018, 239, 300-307.

7.      Xiaoxi Yang, Wenting Song, Na Liu, Zhendong Sun, Ruirui Liu, Qian S Liu, Qunfang Zhou*, Guibin Jiang. Synthetic phenolic antioxidants cause perturbation in steroidogenesis in vitro and in vivo. Environmental Sciences & Technology, 2018, 52(2), 850–858.

8.      Qian S. Liu, Na Liu, Zhendong Sun, Qunfang Zhou*, Guibin Jiang. Intranasal administration of tetrabromobisphenol A bis(2-hydroxyethyl ether) induces neurobehavioral changes in neonatal Sprague Dawley rats. Journal of Environmental Science, 2018, 63, 76-86.

9.      Qian S. Liu, Fang Hao, Zhendong Sun, Yanmin Long, Qunfang Zhou*, Guibin Jiang. Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system. Chemosphere, 2018,190, 191-200.

10.    Fang Hao, XiaotingJin, Qian S. Liu, Qunfang Zhou*, Guibin Jiang. The epidermal penetration of gold nanoparticles and its underlying mechanism based on human reconstructed 3D EpiskinTM model. ACS Applied Materials & Interfaces, 2017, 9(49), 42577-42588.

11.    Xingchen Zhao, Dawei Lu, Qian S. Liu, Yiling Li, Rui Feng, Fang Hao, Guangbo Qu, Qunfang Zhou*, Guibin Jiang. Hematological effects of gold nanorods on erythrocytes: Hemolysis and hemoglobin conformational and functional changes. Advanced Science, 2017, 1700296.

12.    Qian S. Liu, Yuzhen Sun, Guangbo Qu, Yanmin Long, Xingchen Zhao, Aiqian Zhang, Qunfang Zhou*, Ligang Hu*, Guibin Jiang. Structure-dependent hematological effects of per- and polyfluoroalkyl substances on activation of plasma kallikrein-kinin system cascade. Environmental Science & Technology, 2017, 51(17), 10173-10183.

13.    Wenting Song, Lixia Zhao, Zhendong Sun, Xiaoxi Yang, Qunfang Zhou*, Guibin Jiang. A novel high throughput screening assay for binding affinities of perfluoroalkyliodide for estrogen receptor alpha and beta isoforms. Talanta, 2017,175, 413-420.

14.    Xingchen Zhao, Miao Yu, Dan Xu, Aifeng Liu, XingwangHou, Fang Hao, Yanmin Long, Qunfang Zhou*, Guibin Jiang. Distribution, bioaccumulation, trophic transfer, and influences of CeO2 nanoparticles in a constructed aquatic food web. Environmental Science & Technology, 2017, 51(9), 5205-5214.

15.    Yan-Min Long, Li-Gang Hu, Xue-Ting Yan, Xing-Chen Zhao, Qun-Fang Zhou*, Yong Cai, Gui-Bin Jiang. Surface ligand controls silver ion release of nanosilver and its antibacterial activity against Escherichia coli. International Journal of Nanomedicine, 2017, 12, 3193-3206.

16.    Ruoxi Wen, Ligang Hu, Guangbo Qu, Qunfang Zhou*, Guibin Jiang. Exposure, tissue biodistribution, and biotransformation of nanosilver. NanoImpact, 2016, 2, 18-28.

17.    Qian Liu, Xiaomin Ren, Yanmin Long, Ligang Hu, Guangbo Qu, Qunfang Zhou*, Guibin Jiang. The potential neurotoxicity of emerging tetrabromobisphenol A derivatives based on rat pheochromocytoma cells. Chemosphere, 2016, 154, 194-203.

18.    Cheng Sun, Nuoya Yin, Ruoxi Wen, Wei Liu, Yanxia Jia, Ligang Hu, Qunfang Zhou*, Guibin Jiang. Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions. Neurotoxicology, 2016, 52, 210-221.

19.    Wei Liu, Cheng Sun, Chunyang Liao, Lin Cui, Haishan Li, Guanbo Qu, Wenlian Yu, Naining Song, Yuan Cui, Zheng Wang, WenpingXie, Huiming Chen*, Qunfang Zhou*. Graphene enhances cellular proliferation through activating the epidermal growth factor receptor. Journal of Agricultural and Food Chemistry, 2016, 64, 5909-5918.

20.    Ruoxi Wen, Xiaoxi Yang, Ligang Hu, Cheng Sun, Qunfang Zhou*, Guibin Jiang. Brain-targeted distribution and high retention of silver by chronic intranasal instillation of silver nanoparticles and ions in Sprague–Dawley rats. Journal of Applied Toxicology, 2016, 36, 445-453.

21.    Yan-Min Long, Xing-Chen Zhao, Allen C. Clermont, Qun-Fang Zhou*, Qian Liu, Edward P. Feener, Bing Yan, Gui-Bin Jiang*. Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction. Nanotoxicology, 2016, 10, 501-511.

22.    Xingchen Zhao, Fang Hao, Dawei Lu, Wei Liu, Qunfang Zhou*, Guibin Jiang. Influence of the surface functional group density on the carbon nanotube-induced alpha-chymotrypsin structure and activity alterations. ACS Applied Materials & Interfaces, 2015, 7, 18880-18890.

23.    Nuoya Yin, Yang Zhang, Zhaojun Yun, Qian Liu, Guangbo Qu, Qunfang Zhou*, Ligang Hu, Guibin Jiang. Silver nanoparticle exposure induces rat motor dysfunction through decrease in expression of calcium channel protein in cerebellum. Toxicology Letters, 2015, 237, 112-120.

24.    Weijin Yang, Jianjie Fu, Thanh Wang, Hanxia Liu, Yawei Wang, Qunfang Zhou*, Guibin Jiang. Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches. Journal of Environmental Sciences, 2014, 26(4), 900-908.

25.    Nuoya Yin, Qian Liu, Jiyan Liu, Bin He, Lin Cui, Zhuona Li, Zhaojun Yun, Guangbo Qu, Sijin Liu, Qunfang Zhou*, Guibin Jiang. Silver nanoparticles exposure attenuates the viability of rat cerebellum granule cells through apoptosis coupled to oxidative stress. Small, 2013, 9(9-10): 1831-1841.

26.    Zhuona Li, Nuoya Yin, Qian Liu, Chang Wang, Thanh Wang, Yichen WangGuangbo Qu, Jiyan Liu, YaqiCai, Qunfang Zhou*, Guibin Jiang. Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells. Chemosphere, 2013, 90(3), 1227-1235.

27.    Edward P. Feener, Qunfang Zhou, Ward Fickweiler. Role of plasma kallikrein in diabetes and metabolism. Journal of Thrombosis and Haemostasis, 2013, 110(3), 434-41.

28.    Yichen Wang, Qunfang Zhou, Chang Wang, Nuoya Yin, Zhuona Li, Jiyan Liu, Guibin Jiang*. Estrogen-like response of perfluorooctyl iodide in male medaka (Oryziaslatipes) based on hepatic vitellogenin induction. Environmental Toxicology, 2013, 28(10), 571-578.

29.    Yuan Wu, Qunfang Zhou. Silver nanoparticles cause oxidative damage and histological changes in medaka (Oryziaslatipes) after 14 days of exposure. Environmental Toxicology and chemistry, 2013, 32(1), 165-173.

30.    Chang Wang, Thanh Wang, Wei Liu, Ting Ruan, Qunfang Zhou, Jiyan Liu, Aiqian Zhang, Bin Zhao, Guibin Jiang. The in vitro estrogenic activities of polyfluorinated iodine alkanes. Environmental Health Perspectives, 2012, 120(1), 119-125.

31.    Yuan Wu, Qunfang Zhou. Dose- and time-related changes in aerobic metabolism, chorionic disruption, and oxidative stress in embryonic medaka (Oryziaslatipes): Underlying mechanisms for silver nanoparticle developmental toxicity. Aquatic Toxicology, 2012, 124125, 238-246.

32.    Qunfang Zhou, Sergey A. Dergunov, Yi Zhang, Xi Li, Qingxin Mu, Qiu Zhang, Guibin Jiang, Eugene Pinkhassik, Bing Yan*. Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls. Nanoscale, 2011, 3(6), 2576-2582.

 

 

  

 

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