黄春华

发布时间:2019-07-13  |  【打印】 【关闭

  
姓名:黄春华性别:男职称:助理研究员电话:010-62849321E-mail:chhuang@rcees.ac.cn组别:自由基化学与复合毒理研究组研究方向:环境自由基化学及DNA损伤机理
  

      简历:

  教育经历/br> 2007/09-2013/06,中国科学院生态环境研究中心 环境化学与生态毒理国家重点实验室 环境科学,博士 导师:朱本占研究员/br> 2003/09-2007/06,中国石油大学(北京) 资源与信息学院 获学士学位/br> 工作经历/br> 2015/08-至今,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,助理研究员/br> 2013/07-2015/08,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,博士后

 

  承担科研项目:

  1. 国家自然科学基金面上项目,21777180,多环芳胺致癌的新型光致活性自由基的生成及DNA损伤机理研究, 2018/01-2021/12,64万元,在研,主持。

  2. 国家自然科学基金青年基金项目,21407163,四氯邻苯二酚与叠氮钠协同毒性分子机理,2014/01-2017/12,26万元,结题,主持。

  

  代表论著:

 

1.      Xu D, Huang C H*, Xie L N, Shao B, Mao L, Shao J, Kalyanaraman B, Zhu B Z*, Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens, Carcinogenesis, 2019:

2.      Huang C H, Ren F R, Shan G Q, Qin H, Mao L, Zhu B Z*, Molecular Mechanism of Metal-Independent Decomposition of Organic Hydroperoxides by Halogenated Quinoid Carcinogens and the Potential Biological Implications, Chem Res Toxicol, 2015,28(5): 831-837

3.      Huang C H, Shan G Q, Mao L, Kalyanaraman B, Qin H, Ren F R, Zhu B Z*, The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct, Chem Commun, 2013,49(57): 6436-6438

4.      Zhu B Z*, Chao X J, Huang C H, Li Y, Delivering the cell-impermeable DNA ‘lightswitching’Ru(II) complexes preferentially into live cell nucleus via an unprecedented ion-pairing method, Chem Sci, 2016,(7): 4016-4023

5.      Zhu B Z*, Mao L, Huang C H, Qin H, Fan R M, Kalyanaraman B, Zhu J G, Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2, Proc Natl Acad Sci USA, 2012,109(40): 16046-16051

6.      Zhu B Z*, Shan G Q, Huang C H, Kalyanaraman B, Mao L, Du Y G, Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical, Proc Natl Acad Sci USA, 2009,106(28): 11466-11471

7.      Li F, Huang C H, Xie L N, Qu N, Shao J, Shao B, Zhu B Z*, An Exceptionally Facile Two-Step Structural Isomerization and Detoxication via a Water-Assisted Double Lossen Rearrangement, Sci Rep, 2016,6:

8.      Li Y, Huang C H, Liu Y X, Mao L, Zhu B Z*, Detoxifying Polyhalogenated Catechols through a Copper-Chelating Agent by Forming Stable and Redox-Inactive Hydrogen-Bonded Complexes with an Unusual Perpendicular Structure, Chemistry-a European Journal, 2014,20(40): 13028-13033

9.      Shao J, Huang C H, Kalyanaraman B, Zhu B Z*, Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism, Free Radic Biol Med, 2013,60: 177-182

10.   Qin H, Huang C H, Mao L, Xia H Y, Kalyanaraman B, Shao J, Shan G Q, Zhu B Z*, Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens, Free Radic Biol Med, 2013,63: 459-466

11.   Mao L, Liu Y X, Huang C H, Gao H Y, Kalyanaraman B, Zhu B Z*, Intrinsic Chemiluminescence Generation during Advanced Oxidation of Persistent Halogenated Aromatic Carcinogens, Environ Sci Technol, 2015,49(13): 7940-7947

12.   Shao B, Mao L, Qu N, Wang Y F, Gao H Y, Li F, Qin L, Shao J, Huang C H, Xu D, Xie L N, Shen C, Zhou X, Zhu B Z*, Mechanism of synergistic DNA damage induced by the hydroquinone metabolite of brominated phenolic environmental pollutants and Cu(II): Formation of DNA-Cu complex and site-specific production of hydroxyl radicals, Free Radic Biol Med, 2017,104: 54-63

13.   Gao H Y, Mao L, Li F, Xie L N, Huang C H, Shao J, Shao B, Kalyanaraman B, Zhu B Z*, Mechanism of Intrinsic Chemiluminescence Production from the Degradation of Persistent Chlorinated Phenols by the Fenton System: A Structure-Activity Relationship Study and the Critical Role of Quinoid and Semiquinone Radical Intermediates, Environ Sci Technol, 2017,51(5): 2934-2943

14.   Gao H Y, Mao L, Shao B, Huang C H, Zhu B Z*, Why Does 2,3,5,6-Tetrachlorophenol Generate the Strongest Intrinsic Chemiluminescence among All Nineteen Chlorophenolic Persistent Organic Pollutants during Environmentally-friendly Advanced Oxidation Process?, Sci Rep, 2016,6:

15.   Shan G Q, Yu A, Zhao C F, Huang C H, Zhu L Y, Zhu B Z*, A Combined Experimental and Computational Investigation on the Unusual Molecular Mechanism of the Lossen Rearrangement Reaction Activated by Carcinogenic Halogenated Quinones, J Org Chem, 2015,80(1): 180-189

16.   Li L X Y, Hu L G, Zhou Q F, Huang C H, Wang Y W*, Sun C, Jiang G B, Sulfidation as a Natural Antidote to Metallic Nanoparticles Is Overestimated: CuO Sulfidation Yields CuS Nanoparticles with Increased Toxicity in Medaka (Oryzias latipes) Embryos, Environ Sci Technol, 2015,49(4): 2486-2495

17.   Zhu B Z*, Shao B, Li F, Liu Y X, Huang C H, An Unusual Double Lossen Rearrangement Reaction: The Novel Molecular Detoxication Mechanism for Hydroxamic Acids, Acta Chim Sin, 2015,73(8): 765-769

  

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