李圆圆

发布时间:2019-06-04  |  【打印】 【关闭

  
姓名:李圆圆性别:女职称:助理研究员电话:010-62919177E-mail:yyli@rcees.ac.cn组别:内分泌干扰物与发育毒性研究组研究方向:生殖内分泌干扰
  

简历:

  2019/6-至今, 中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 助理研究员

  2017/8-2019/5, 中国科学院生态环境研究中心, 博士后,合作导师:郑明辉/秦占芬 研究员

  2012/9–2017/7,中国科学院生态环境研究中心,环境科学,博士,导师: 秦占芬

  2007/9–2011/7, 太原科技大学, 环境科学, 学士

  社会任职:

  中国化学会会员、中国毒理学会会员

  承担科研项目:

  1. 国家自然科学基金青年项目,胞外基质参与环境雌激素诱导两栖动物雌性化的机制研究,2020/01-2021/12,20万元,在研,主持。

  2. 博士后科学基金面上项目,2017M620929,环境雌激素诱导两栖动物雌性化的有害结局路径,2017/11-2019/05,5万元,结题,主持。

  3. 自然科学基金面上项目,21677166,环境雌激素诱导两栖动物雌性化的分子机制研究,2017/01-2020/12,70万元,在研,参加。

  3. 中国科学院先导专项B子课题,XDB14040102,甲状腺激素信号介导的化学污染物脑发育毒性研究,2014/07-2019/07,475万元,在研,参加。

  获奖及荣誉:

  2016年教育部博士研究生国家奖学金

  2014年教育部硕士研究生国家奖学金

  2010年教育部本科生国家奖学金

  代表论著:

1.       Yuan-Yuan Li, Jin-Bo Li, Yan-Ping Shen, Yi-Ming Xiong, Xing-Hong Li, Zhan-Fen Qin* 2021 Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis. Aquatic Toxicology 232, 105760.

2.       Yuan-Yuan Li, Yan-Ping Shen, Jin-Bo Li, Man Cai, Zhan-Fen Qin*. Transcriptomic analysis identifies early cellular and molecular events by which estrogen disrupts testis differentiation and causes feminization in Xenopus laevis. Aquatic Toxicology. 2020, 226: 105557.

3.       Yuan-Yuan Li, Jin-Bo Li, Man Cai, Zhan-Fen Qin* Development of testis cords and the formation of efferent ducts in Xenopus laevis: differences and similarities with other vertebrates. Sexual Development, DOI: 10.1159/000513416

4.       Yuan-Yuan Li, Tan Meng, Kun Gao, Zhan-Fen Qin*. Gonadal differentiation and its sensitivity to androgens during development of Pelophylax nigromaculatus. Aquatic Toxicology, 2018, 202: 188-195.

5.       Yuan-Yuan Li, Juan Chen, Zhan-Fen Qin*. Determining the optimal developmental stages of Xenopus laevis for initiating exposures to chemicals for sensitively detecting their feminizing effects on gonadal differentiation. Aquatic Toxicology, 2016, 179: 134–142.

6.       Yuan-Yuan Li, Wei Xu, Xiao-Ran Chen, Qin-Qin Lou, Wu-Ji Wei, Zhan-Fen Qin*. Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus. Aquatic Toxicology, 2015, 58: 230–237.

7.       Wei Xu#, Yuan-Yuan Li#, Qin-Qin Lou, Xiao-Ran Chen, Zhan-Fen Qin *, Wu-Ji Wei *. Low concentrations of dihydrotestosterone induce female-to-male sex reversal in the frog Pelophylax nigromaculatus. Environmental Toxicology and Chemistry, 2015, 34(10): 2370-2377. (# Co-first author)

8.       李圆圆,付旭峰,赵亚娴,苏红巧,秦占芬*. 双酚A与其替代品对黑斑蛙急性毒性的比较. 生态毒理学报, 2015, 10 (2):251-257.

9.       Xiao-Ying Chen, Yuan-Yuan Li, Min Zhu, Zhan-Fen Qin*. An ex vivo assay for screening glucocorticoid signaling disruption based on glucocorticoid-response gene transcription in Xenopus tails. Journal of Environmental Sciences, 2018, 66: 104-112.

10.     Yao Wang, Yuan-Yuan Li, Zhan-Fen Qin*, Wu-Ji Wei*. Re-evaluation of thyroid hormone signaling antagonism of tetrabromobisphenol A for validating the T3-induced Xenopus metamorphosis assay. Journal of Environmental Sciences, 2017, 52: 325-332.

11.     Ya-Xian Zhao, Yuan-Yuan Li, Xiao-Fei Qin, Qin-Qin Lou, Zhan-Fen Qin*. Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site. Environmental Pollution, 2016, 218: 1334-1341.

12.     Yin-Feng Zhang, Yuan-Yuan Li, Zhan-Fen Qin*, Hui-Li Wang *, Jian-Zhong Li. A screening assay for thyroid hormone (TH) signaling disruption based on TH-response gene expression analysis in the frog Pelophylax nigromaculatus. Journal of Environmental Sciences, 2015, 34: 143-154.

 

 

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