简历：

　　教育经历

　　2002/09-2005/07，湖南大学 化学生物传感与计量学国家重点实验室 分析化学，博士 导师：俞汝勤院士

　　1999/09-2002/07，山西大学化学化工学院 分析化学，硕士 导师：双少敏教授

　　工作经历

　　2011/03-至今，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，副研究员，硕士生导师

　　2008/09-2011/02，中国科学院生态环境研究中心，环境化学与生态毒理学国家重点实验室，助理研究员2006/09-2008/08，北京大学，化学与分子工程学院，分析化学研究所 博士后 合作导师：刘锋教授

　　承担科研项目：

　　1. 国家自然科学基金面上项目，21577163，全氟化合物毒性作用新靶点蛋白质酪氨酸磷酸酶的识别及分子机制研究，2016/01-2019/12，80万，在研，主持。

　　2. 国家自然科学基金面上项目，21377142，环境污染物对蛋白质可逆糖基化过程干扰效应的快速筛查和干扰机制研究， 2014/01-2017/12，80万元，结题，主持。

　　3. 国家自然科学基金面上项目，21077124，基于超分子荧光分子开关体系实时动态高通量研究二恶英对氨基酸脱羧酶的毒性作用，2011/01-2013/12，35万元，结题，主持。

　　4. 国家自然科学基金青年基金项目，20907068，共振光散射法研究多环芳烃代谢物与p53基因的相互作用和基因毒性，2010/01-2012/12，19万元，结题，主持。

　　5. 中国博士后基金一等资助项目，20070410017，基于电纺丝与分子印迹技术相结合的新型超分子化学传感器的研究，5万，2007/10-2008/09，结题，主持。

　　6. 中科院战略先导科技专项B，XDB14040100,典型污染物的内分泌干扰效应与发育毒性，2014/07-2019/06，在研，参加

　　7. 国家973项目，2010CB933600，纳米材料与纳米技术在水污染物检测与治理中的应用基础研究，2010/01-2014/08，结题，参加。

　　8. 中国科学院知识创新工程重要方向项目，KSCX2-YW-G-059，用于磺酰脲类除草剂快速检测的纳米生物传感器技术研究，2009/01-2011/12，结题，参加。

　　代表论著：

1.     Yuxin Gu, Yu Yang*, Bin Wan, Minjie Li, Liang-Hong Guo*. Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells – A molecular mechanism of organophosphate flame retardants developmental neurotoxicity. Biochemical Pharmacology. 2018, 152, 21-33.

2.     Lin-Ying Cao, Xiao-Min Ren*, Yu Yang, Bin Wan, Liang-Hong Guo*, De Chen, Yong Fan. Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-genomic G Protein-Coupled Estrogen Receptor Mediated Pathways. Environmental Health Perspectives. 2018, 126, 057005.

3.     Yan Xin, Bin Wan*, Yu Yang, Xue-Jing Cui, Yi-Chun Xie, Liang-Hong Guo*. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. Archives of Toxicology. 2018, 92, 3131–3147.

4.     Yu Yang*, Yuxin Gu, Bin Wan, Xiaomin Ren, Liang-Hong Guo*. Label-free electrochemical biosensing of small-molecule inhibition on O-GlcNAc glycosylation. Biosensors & Bioelectronics, 2017, 95, 94-99.

5.     Yu Yang, Qi-Yan Lv, Liang-Hong Guo*, Bin Wan, Xiao-Min Ren, Ya-Li Shi, Ya-Qi Cai. Identification of Protein Tyrosine Phosphatase SHP-2 as a New Target of Perfluoroalkyl Acids in HepG2 Cells. Archives of Toxicology, 2017, 91, 1697-1707.

6.     Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*. Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. Scientific Reports, 2017, 7, 1518.

7.     Sufang Wang, Qiyan Lv, Yu Yang*, Liang-Hong Guo*, Bin Wan, Xiaomin Ren, Hui Zhang. Arginine Decarboxylase: a Novel Biological Target of Mercury Compounds Identified in PC12 Cells. Biochemical Pharmacology, 2016, 118, 109-120.

8.     Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, and Hui Zhang. Crucial role of P2X7 receptor in regulating exocytosis of single-walled carbon nanotubes in macrophages. Small, 2016, 12, 5998-6011.

9.     Jie Hou, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*, and Jingfu Liu. Biodegradation of single-walled carbon nanotubes in macrophages through respiratory burst modulation. International Journal of Molecular Sciences, 2016, 17, 409-426.

10.   Xiaomin Ren, Linying Cao, Yu Yang, Bin Wan, Sufang Wang, Liang-Hong Guo*. In vitro assessment of thyroid hormone receptor activity of four organophosphate esters. Journal of Environmental Sciences, 2016, 45, 185-190.

11.   Xuejing Cui, Bin Wan*, Liang-Hong Guo*, Yu Yang, and Xiaomin Ren. Insight into the mechanisms of combined toxicity of single-walled carbon nanotubes and nickel ions in macrophages: role of P2X7 receptor. Environmental Science & Technology, 2016, 50, 12473-12483.

12.   Sufang Wang, Qiyan Lv, Yu Yang*, Liang-Hong Guo*, Bin Wan, Lixia Zhao. Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase. Science of the Total Environment, 2014, 496, 381-388.

13.   Sufang Wang, Bin Wan, Lianying Zhang, Yu Yang*, Liang-Hong Guo*. In vitro inhibition of lysine decarboxylase activity by organophosphate esters. Biochemical Pharmacology, 2014, 92, 506-516.

14.   Yu Yang, Liang-Hong Guo*, Na Qu, Ming-Yuan Wei, Li-Xia Zhao, Bin Wan. Label-free electrochemical measurement of protein tyrosine kinase activity and inhibition based on electro-catalyzed tyrosine signaling. Biosensors and Bioelectronics, 2011, 28, 284-290.

15.   Yu Yang, Lixia Zhao*. Sensitive fluorescent sensing for DNA assay. Trends in Analytical Chemistry, 2010, 29, 980-1003.

16.   Yu Yang, Jianhui Jiang, Guoli Shen, Ruqin Yu*. An optical sensor for mercury ion based on the fluorescence quenching of tetra(p-dimethylaminophenyl)porphyrin. Analytica Chimica Acta, 2009, 636, 83-88.

17.   Yu Yang, Yuanyuan Long, Zhiyu Li, Na Li, Kean Li, Feng Liu*. Real-time molecular recognition between protein and photosensitizer of photodynamic therapy by quartz crystal microbalance sensor. Analytical Biochemistry, 2009, 392, 22-27.

18.   Yu Yang, Yuanyuan Long, Qing Cao, Kean Li, Feng Liu*. Molecularly imprinted polymer using beta-cyclodextrin as functional monomer for the efficient recognition of bilirubin. Analytica Chimica Acta, 2008, 606, 92-97.