邵杰

发布时间:2019-07-13  |  【打印】 【关闭

  
姓名:邵杰性别:女职称:副研究员电话:010-62849321E-mail:jieshao@rcees.ac.cn组别:自由基化学与复合毒理研究组研究方向:环境污染物导致DNA损伤机理及其基因毒性研究
  

      简历:

  教育经历

  2004/09-2010/06,纽约大学化学系 生物化学 博士 导师:Nicholas Geacintov

  2000/09-2004/06,北京大学化学分子工程学院 学士

  工作经历

  2011/01-至今,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,助理研究员

  

  承担科研项目:

  1. 中心青年科学基金资助项目,RCEES-QN-20130052F,致癌性卤代醌介导的脂质氢过氧化物分解反应诱导DNA氧化损伤的机理研究,2014/01-2015/07, 25万。

  2. 国家自然科学青年基金项目,21207150,致癌性卤代醌和过氧化氢诱导DNA氧化损伤的机理研究,2013/01-2015/12,27万

  

  代表论著:

1.      Shao J, Huang CH, Kalyanaraman B, Zhu BZ* (2013) Potent methyl oxidation of 5-methyl-2’-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic. Biol. Med. 60, 177-182

2.      Shao J, Geacintov N. E., Shafirovich V.* (2010) Oxidative modification of guanine bases initiated by oxyl radicals derived from photolysis of azo compounds. J. Phys. Chem. B 114: 6685-6692.

3.      Shao J, Geacintov N. E., Shafirovich V.* (2010) Oxidation of 8-oxo-7,8-dihydro-2’ -deoxyguanosine by oxyl radicals produced by photolysis of azo compounds. Chem. Res. Toxicol. 23: 933-938.

4.      Xie LN, Shao J, Huang CH, Li F, Xu D, Kalyanaraman B, Zhu BZ*, An Unusual Double Radical Homolysis Mechanism for the Unexpected Activation of the Aldoxime Nerve-Agent Antidotes by Polyhalogenated Quinoid Carcinogens under Normal Physiological Conditions Free Radic. Biol. Med. (2019) 130:1-7

5.      Crean C., Shao J, Yun B. H., Geacintov N. E., Shafirovich V.* (2009) The role of one-electron reduction of lipid   hydroperoxides in causing DNA damage. Chem. Eur. J. 15(40):10634-10640.

6.      Chao XJ, Tang M, Huang R, Huang CH, Shao J, Yan ZY, Zhu BZ* (2019) Targeted Live-Cell Nuclear Delivery of the DNA ‘Light-switching’ Ru(II) Complex via Ion-Pairing with Chlorophenolate Counter-Anions: The Critical Role of Binding Stability and Lipophilicity of the Ion-Pairing Complexes. Nucleic Acids Res. (Accepted)

7.      Xu D, Huang CH, Xie LN, Shao B, Mao L, Shao J, Kalyanaraman B, Zhu BZ* (2019) Mechanism of Unprecedented Hydroxyl Radical Production and Site-Specific Oxidative DNA Damage by Photo Activation of the Classic Arylhydroxamic Acid Carcinogens. Carcinogenesis, doi:10.1093/carcin/bgz021

8.      Zhu BZ*, Shen C, Gao HY, Zhu LY, Shao J, Mao L* (2017) Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure–activity relationship and potential applications. J. Environ. Sci. 62: 68-83

9.      Shao B, Mao L, Qu N, Wang YF, Gao HY, Li F, Qin L, Shao J, Xu D, Huang CH, Xie LN, Shen C, Zhou X, Zhu BZ* (2017) Mechanism of synergistic DNA damage induced by the hydroquinone metabolite of brominated phenolic environmental pollutants and Cu(II): formation of DNA-Cu complex and site-specific production of hydroxyl radicals.  Free Radic. Biol. Med., 104:54-63

10.    Gao HY, Mao L, Li F, Xie LN, Huang CH, Shao J, Shao B, Kalyanaraman B, Zhu BZ* (2017) Mechanism of Intrinsic Chemiluminescence Production from the Degradation of Persistent Chlorinated Phenols by the Fenton System: A Structure-Activity Relationship Study and the Critical Role of Quinoid and Semiquinone Radical Intermediates. Environ. Sci. Technol. 51(5):2934-2943

11.    Li F, Huang CH, Xie LN, Qu N, Shao J, Shao B, Zhu BZ* (2016) An exceptionally facile two-step structural isomerization and detoxication via a water-assisted double Lossen rearrangement. Sci. Rep. 6: 39207.

12.    Qu N, Li F, Shao B, Shao J, Zhai GJ, Wang FY, Zhu BZ* (2016) The Unexpected and Exceptionally Facile Chemical Modification of the Phenolic Hydroxyl Group of Tyrosine by Polyhalogenated Quinones under Physiological Conditions, Chem. Res. Toxi., 29(10): 1699-1705

13.    Qin H, Huang CH, Mao L, Xia HY, Kalyanaraman B, Shao J, Shan GQ, Zhu BZ* (2013) Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic. Biol. Med. 63459-466

  

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