谢群慧

发布时间:2019-06-12  |  【打印】 【关闭

  
姓名:谢群慧 [硕士生导师]性别:女职称:副研究员电话:010-62842865E-mail:qhxie@rcees.ac.cn组别:分子环境毒理研究组研究方向:二恶英类污染物的神经毒理效应及机制研究招生专业:环境科学、生物化学与分子生物学、神经生物学
  

简历:

  教育经历

  2002/09–2006/12,香港科技大学,生物系,博士,导师:詹华强教授

  1995/09–2002/06,北京大学,医学部,学士及硕士,导师:王薇薇教授

  工作经历

  2010/05-至今,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,副研究员2008/01-2008/07,巴黎高等师范学院,生物系,博士后,合作导师:Jean Massoulié

  2007/03-2010/03,香港科技大学,生物系,高级研究助理

  社会任职:

  1. 中华预防医学会卫生毒理分会青年委员会委员

  承担科研项目:

  1、中科院战略性先导科技专项B类子课题,XDB14030402,典型污染物导致信号通路扰动与其生物效应的关联机制,2014/07-2019/06,490万元,在研,主持

  2、国家自然科学基金面上项目,21377160,二恶英类污染物对神经胶质细胞分化和功能的影响及相关作用机制,2014/01-2017/12,90万元,已结题,主持

  3、国家自然科学基金委面上项目,21277168,二恶英免疫毒理效应的分子作用靶点及机理研究,2013/01-2016/12,80万元,已结题,参加

  4、国家自然科学基金委面上项目,21177150,二恶英类污染物神经毒理作用新机制的研究,2012/01-2015/12,65万元,已结题,参加

  5、中国科学院知识创新工程重要方向项目,KZCX2-EW-411,二恶英类污染物免疫毒性的分子机理研究,2011/01-2013/12,150万元,已结题,参加

  获奖及荣誉:

 

  代表论著:

1.     Qunhui Xie, Yingjie Xia, Tuan Xu, Yangsheng Chen, Hualing Fu, Yunping Li, Yali Luo, Li Xu, Karl W K Tsim, Bin Zhao. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces alterations in myogenic differentiation of C2C12 cells. Environmental Pollution, 2018, 235, 965-973.

2.     SongYan Zhang ShuaiZhang Li, ZhiGuang Zhou, HuaLing Fu, Li Xu, Heidi Qunhui Xie,   Bin Zhao. Development and Application of a Novel Bioassay System for Dioxin Determination and Aryl Hydrocarbon Receptor Activation Evaluation in Ambient-Air Samples. Environmental Science & Technology, 2018, 52, 2926-2933.

3.     Tuan Xu, Qunhui Xie, Yunping Li, Yingjie Xia, Rui Sha, Lingyun Wang, Yangsheng Chen, Li Xu, Bin Zhao. Dioxin induces expression of hsa-mi R-146b-5p in human neuroblastoma cells. Journal of Environmental Sciences, 2018, 63, 260-267.

4.     Yangsheng Chen, Li Xu, Heidi Q. Xie, Tuan Xu, Hualing Fu, Songyan Zhang, Rui Sha, Yingjie Xia, Bin Zhao. Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure, J Environ Sci (China), 2017, 62, 92-99.

5.     Tuan Xu, Heidi Q. Xie, Yunping Li, Yingjie Xia, Yangsheng Chen, Li Xu, Lingyun Wang, Bin Zhao. CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells, Scientific Reports, 2017, 7(1), 10103.

6.     Heidi Q. Xie, Tuan Xu, Yangsheng Chen, Yunping Li., Yingjie Xia., Li Xu, Lingyun Wang, Karl W.K. Tsim, Bin Zhao. New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-Biological Interactions, 2016, 259, 286-290.

7.     Jijing Tian, Yu Feng, Hualing Fu, Heidi Q. Xie, Joy X. Jiang, Bin Zhao. The Aryl Hydrocarbon Receptor: A key bridging molecule of external and internal chemical signals, Environ Sci Technol. 2015, 49(16), 9518-9531.

8.     Xianghui Zou, Heidi Q. Xie, Guangcai Zha, Vicky P. Chen, Yanjie Sun, Yuzhong Zheng, Karl W.K. Tsim, Tina T.X. Dong, Roy C.Y. Choi, Wilson K. Luk. Characterizations of cholinesterases in golden apple snail (Pomacea canaliculata). Journal of Molecular Neuroscience, 2014, 53(3), 424-428.

9.     Heidi Q. Xie, Haiming Xu, Hualing Fu, Qin Hu, Wenjing Tian, Xinhui Pei, Bin Zhao. AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro, Environmental Health Perspectives, 2013, 121(5), 613-618.

10.   Heidi Q Xie, Dong Liang, Wing K. Leung, Vicky P. Chen., Kelvin Y. Zhu, Wallace K Chan, Roy C. Choi, Jean Massoulié., Karl W. K. Tsim. Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons. Journal of Biological Chemistry, 2010, 285(15), 11537-11546.

 

  

 

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