李圆圆
简历：
2019/6-至今, 中国科学院生态环境研究中心, 环境化学与生态毒理学国家重点实验室, 助理研究员
2017/8-2019/5, 中国科学院生态环境研究中心, 博士后，合作导师：郑明辉/秦占芬 研究员
2012/9–2017/7，中国科学院生态环境研究中心，环境科学，博士，导师: 秦占芬
2007/9–2011/7, 太原科技大学, 环境科学, 学士
社会任职：
中国化学会会员、中国毒理学会会员
承担科研项目：
1. 国家自然科学基金青年项目，胞外基质参与环境雌激素诱导两栖动物雌性化的机制研究，2020/01-2021/12，20万元，在研，主持。
2. 博士后科学基金面上项目，2017M620929，环境雌激素诱导两栖动物雌性化的有害结局路径，2017/11-2019/05，5万元，结题，主持。
3. 自然科学基金面上项目，21677166，环境雌激素诱导两栖动物雌性化的分子机制研究，2017/01-2020/12，70万元，在研，参加。
3. 中国科学院先导专项B子课题，XDB14040102，甲状腺激素信号介导的化学污染物脑发育毒性研究，2014/07-2019/07，475万元，在研，参加。
获奖及荣誉：
2016年教育部博士研究生国家奖学金
2014年教育部硕士研究生国家奖学金
2010年教育部本科生国家奖学金
代表论著：
1. Yuan-Yuan Li, Jin-Bo Li, Yan-Ping Shen, Yi-Ming Xiong, Xing-Hong Li, Zhan-Fen Qin* 2021 Identification of estrogen receptor target genes involved in gonadal feminization caused by estrogen in Xenopus laevis. Aquatic Toxicology 232, 105760.
2. Yuan-Yuan Li, Yan-Ping Shen, Jin-Bo Li, Man Cai, Zhan-Fen Qin*. Transcriptomic analysis identifies early cellular and molecular events by which estrogen disrupts testis differentiation and causes feminization in Xenopus laevis. Aquatic Toxicology. 2020, 226: 105557.
3. Yuan-Yuan Li, Jin-Bo Li, Man Cai, Zhan-Fen Qin* Development of testis cords and the formation of efferent ducts in Xenopus laevis: differences and similarities with other vertebrates. Sexual Development, DOI: 10.1159/000513416
4. Yuan-Yuan Li, Tan Meng, Kun Gao, Zhan-Fen Qin*. Gonadal differentiation and its sensitivity to androgens during development of Pelophylax nigromaculatus. Aquatic Toxicology, 2018, 202: 188-195.
5. Yuan-Yuan Li, Juan Chen, Zhan-Fen Qin*. Determining the optimal developmental stages of Xenopus laevis for initiating exposures to chemicals for sensitively detecting their feminizing effects on gonadal differentiation. Aquatic Toxicology, 2016, 179: 134–142.
6. Yuan-Yuan Li, Wei Xu, Xiao-Ran Chen, Qin-Qin Lou, Wu-Ji Wei, Zhan-Fen Qin*. Low concentrations of 17β-trenbolone induce female-to-male reversal and mortality in the frog Pelophylax nigromaculatus. Aquatic Toxicology, 2015, 58: 230–237.
7. Wei Xu#, Yuan-Yuan Li#, Qin-Qin Lou, Xiao-Ran Chen, Zhan-Fen Qin *, Wu-Ji Wei *. Low concentrations of dihydrotestosterone induce female-to-male sex reversal in the frog Pelophylax nigromaculatus. Environmental Toxicology and Chemistry, 2015, 34(10): 2370-2377. (# Co-first author)
8. 李圆圆，付旭峰，赵亚娴，苏红巧，秦占芬*. 双酚A与其替代品对黑斑蛙急性毒性的比较. 生态毒理学报, 2015, 10 (2):251-257.
9. Xiao-Ying Chen, Yuan-Yuan Li, Min Zhu, Zhan-Fen Qin*. An ex vivo assay for screening glucocorticoid signaling disruption based on glucocorticoid-response gene transcription in Xenopus tails. Journal of Environmental Sciences, 2018, 66: 104-112.
10. Yao Wang, Yuan-Yuan Li, Zhan-Fen Qin*, Wu-Ji Wei*. Re-evaluation of thyroid hormone signaling antagonism of tetrabromobisphenol A for validating the T3-induced Xenopus metamorphosis assay. Journal of Environmental Sciences, 2017, 52: 325-332.
11. Ya-Xian Zhao, Yuan-Yuan Li, Xiao-Fei Qin, Qin-Qin Lou, Zhan-Fen Qin*. Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site. Environmental Pollution, 2016, 218: 1334-1341.
12. Yin-Feng Zhang, Yuan-Yuan Li, Zhan-Fen Qin*, Hui-Li Wang *, Jian-Zhong Li. A screening assay for thyroid hormone (TH) signaling disruption based on TH-response gene expression analysis in the frog Pelophylax nigromaculatus. Journal of Environmental Sciences, 2015, 34: 143-154.
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