State Key Laboratory of Environmental Chemistry and Ecotoxicology

Ting Ruan

Date：05-07-2025 | 【 A A A 】 | 【Print】【Close】

Name：Ting Ruan [Doctoral Supervisor] Title：Professor TEL：010-62849124 E-mail：tingruan@rcees.ac.cn Group：Environmental Analysis and Toxicology Research Area: Mass spectrometric analysis, New pollutants, Ecological and health risk assessment

Resume：

Professor in State Key Laboratory of Environmental Chemistry and Toxicology. He graduated from University of Science and Technology of China with a bachelor's degree in 2006, and received the Ph.D. in Environmental Science from the Graduate School of Chinese Academy of Sciences in 2011. In the same year, he joined the Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Since work, he has been engaged in the study of principles and methods for identifying new pollutants. The research has focused on establishing analytical methods, investigating environmental behavior, and assessing environmental effects for both unknown-structure pollutants and existing chemical substances. It leads to the first report on the environmental occurrence and adverse effects of approximately 110 emerging pollutants in 9 chemical categories, including novel brominated flame retardants, endocrine disruptors, perfluorinated compounds, and disinfection byproducts. Among these emerging pollutants, three categories (i.e., per- and polyfluorinated iodides, perfluoroalkyl silanes, analogues of benzotriazole ultraviolet stabilizers) are now listed in chemical management documents of the Stockholm Convention due to their significant pollutant characteristics and environmental hazards. Two chlorinated perfluoroalkyl sulfonic acids have also been included in the U.S. EPA Method 537.1, Method 533, and Method 1633 for global monitoring. He is invited to serve as a member of the UNEP expert group to finalize the official document “PFAS analysis in water for the Global Monitoring Plan of the Stockholm Convention: Set-up and Guideline for Monitoring”, and is an organization committee member of the International Symposium on Poly- and Perfluoroalkyl Substances in the Environment (FLUOROS Global).

Research Interest:

The research interests focus on prioritization of emerging organic pollutants for ecological/health risk assessment, especially the unknown compounds that have not yet been monitored in the environment. The methods primarily used are quantitative structure-property relationship (QSPR) modeling, mass spectrometric nontarget screening (NTS), and effect-directed analysis (EDA). Advanced approaches that hybridize these techniques have also been developed, such as the artificial intelligence (AI)-assisted mass spectrometric screening for the identification of main contributing pollutants in toxicological endpoints. Research areas include: (1) the identification of unknown pollutants, (2) occurrence and fate of contaminants of emerging concern, (3) regional ecological risk assessment, (4) Exposome and Eco-exposome studies, and (5) toxicology studies based on adverse outcome pathways. The goal is to identify the pollutants that can have significant adverse impacts on the environment and to quantify their contributions.

Social Service：

1. Vice Chairman, Mass Spectrometry Branch, China Association for Instrumental Analysis

2. Editorial Advisory Board, Environmental Science & Technology, ACS Publications

3. Editorial Advisory Board, Science Bulletin, Elsevier

Research projects：

1. Strategic Priority Research Program of the Chinese Academy of Sciences, High-throughput identification and screening of new pollutants (2023-2028), Principal Investigator.

2. National Natural Science Foundation of China, New pollutant identification and regional ecological risk assessment based on toxicity prediction (2023-2026), Principal Investigator.

3. National Key Research and Development Program of China, Application of persistent organic pollutant detection, Development and application of quadrupole time-of-flight liquid chromatography-mass spectrometry instrument (2020-2023), Principal Investigator.

4. National Natural Science Foundation of China, Identification of toxic components in atmospheric fine particulate matter (2019-2021), Co-Principal Investigator.

5. National Natural Science Foundation of China, High-resolution mass spectrometry method for characterizing compounds with toxic effects in atmospheric fine particulate matter (2018-2020), Principal Investigator.

6. National Natural Science Foundation of China, Environmental analytical chemistry and environmental pollution chemistry (2017-2019), Principal Investigator.

Awards and honors：

1. In 2023, Grand prize of the Science and Technology Award (CAIA), China Association for Instrumental Analysis

2. In 2022, Young Investigator Awards, Chinese American Chromatography Association

3. In 2021, The 2021 ES&T Reviewer Awards, ACS Publications

4. In 2019, ES&T and ES&T Lett. Virtual Issue: Early Career Scientists, ACS Publications

5. In 2019, Outstanding Membership of the Youth Innovation Promotion Association, Chinese Academy of Sciences

6. In 2018, Young Scientist Award, Chinese Society of Toxicology

7. In 2011, Dean Award, Chinese Academy of Sciences

Representative paper：

1. Wenyuan Su, Wenqing Liang, Zhendong Yang, Xiang Huang, Pu Wang, Jiyan Liu, Ting Ruan*, and Guibin Jiang. Identification and prioritization of emerging organophosphorus compounds beyond organophosphate esters in Chinese estuarine Waters. Environmental Science & Technology 2025, 59, 4080-4091.

2. Yumiao Sun, Ting Ruan*, Bing Yan, Qunfang Zhou, Yongning Wu, Guibin Jiang*. Rethinking the Carcinogenic Classification of Perfluorooctanoic Acid (PFOA). Environmental Science & Technology 2025, 59, 11433-11436.

3. Xiang Huang, Wangjing Zhai, Wenyuan Su, Zhendong Yang, Wenqing Liang, Pu Wang, Ting Ruan*, Guibin Jiang. Exploration of chemical space covered by nontarget screening based on the prediction of chemical substances amenable to LC-HRMS analysis. Environmental Science & Technology Letters 2025, 12, 661–667.

4. Haotian Wang, Xiaoxia Feng, Wenyuan Su, Laijin Zhong, Yanna Liu, Ting Ruan*, Guibin Jiang. Identifying organic chemicals with acetylcholinesterase inhibition in nationwide estuarine waters by machine learning-assisted mass spectrometric screening. Environmental Science & Technology 2024, 58, 22379-22390.

5. Wenqing Liang, Wenyuan Su, Laijin Zhong, Zhendong Yang, Tingyu Li, Yong Liang, Ting Ruan*, Guibin Jiang. Comprehensive characterization of oxidative stress-modulating chemicals using GPT-based text mining. Environmental Science & Technology 2024, 58, 20540-20552.

6. Wenyuan Su, Pengyang Li, Laijin Zhong, Wenqing Liang, Tingyu Li, Jiyan Liu, Ting Ruan*, Guibin Jiang. Occurrence and Distribution of antibacterial quaternary ammonium compounds in Chinese estuaries revealed by machine learning-assisted mass spectrometric analysis. Environmental Science & Technology 2024, 58, 11707-11717.

7. Pengyang Li, Wenyuan Su, Laijin Zhong, Haotian Wang, Xiang Huang, Ting Ruan*, and Guibin Jiang. Occurrence and ecological risk of alkylamine triazines in Chinese estuarine sediments: An emerging class of persistent, mobile, and toxic substances. Environmental Science & Technology 2024, 58, 6814-6824.

8. Haotian Wang, Laijin Zhong, Wenyuan Su, Ting Ruan*, Guibin Jiang. Machine learning-assisted identification of environmental pollutants by liquid chromatography coupled with high-resolution mass spectrometry. TrAC Trends in Analytical Chemistry 2024, 117988.

9. Laijin Zhong, Bao Zhu, Wenyuan Su, Wenqing Liang, Haotian Wang, Tingyu Li, Dong Cao, Ting Ruan*, Jianmin Chen, Guibin Jiang. Molecular characterization of diverse quinone analogs for discrimination of aerosol-bound persistent pyrolytic and photolytic radicals. Science Bulletin 2024, 69, 612-620.

10. Ting Ruan, Pengyang Li, Haotian Wang, Tingyu Li, and Guibin Jiang*. Identification and prioritization of environmental organic pollutants: From an analytical and toxicological perspective. Chemical Reviews 2023, 123, 10584-10640.

11. Tingyu Li, Wenyuan Su, Laijin Zhong, Wenqing Liang, Xiaoxia Feng, Bao Zhu, Ting Ruan*, Guibin Jiang. An integrated workflow assisted by in silico predictions to expand the list of priority polycyclic aromatic compounds. Environmental Science & Technology 2023, 57, 20854-20863.

12. Pengyang Li, Wenyuan Su, Wenqing Liang, Bao Zhu, Tingyyu Li, Ting Ruan*, Guibin Jiang. Occurrence and temporal trends of benzotriazole UV stabilizers in mollusks (2010-2018) from the Chinese Bohai Sea revealed by target, suspect, and nontarget screening analysis. Environmental Science & Technology 2022, 56, 16759-16767.

13. Xiaoxia Feng, Helin Sun, Xing Liu, Bao Zhu, Wenqing Liang, Ting Ruan*, Guibin Jiang. Occurrence and ecological impact of chemical mixtures in a semiclosed sea by suspect screening analysis. Environmental Science & Technology 2022, 56, 10681-10690.

14. Ting Ruan*, Jennifer Field, Ian Cousins, Rainer Lohmann, Guibin Jiang. Emerging contaminants: Fluorinated alternatives to existing PFAS. Environmental Science & Technology 2022, 56, 6001-6003.

15. Xiaoxia Feng, Dong Li, Wenqing Liang, Ting Ruan*, Guibin Jiang. Recognition and prioritization of chemical mixtures and transformation products in Chinese estuarine waters by suspect screening analysis. Environmental Science & Technology 2021, 55, 9508-9517.

16. Dong Li, Wenqing Liang, Xiaoxia Feng, Ting Ruan*, and Guibin Jiang. Recent advances in data-mining techniques for measuring transformation products by high-resolution mass spectrometry. TrAC Trends in Analytical Chemistry 2021, 143, 116409.

17. Xueke Liu, Yongfeng Liu, Ting Ruan*, and Guibin Jiang. Identification of N‑nitrosamines and nitrogenous heterocyclic byproducts during chloramination of aromatic secondary amine precursors. Environmental Science & Technology 2020, 54, 12949-12958.

18. Xueke Liu, Ruirui Liu, Bao Zhu, Ting Ruan*, and Guibin Jiang. Characterization of carbonyl disinfection by-products during ozonation, chlorination and chloramination of dissolved organic matters. Environmental Science & Technology 2020, 54, 2218-2227.