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  • Free Radical Chemistry and Combination Toxicology


    Free Radical Chemistry and Combination Toxicology Group focuses on the study of free radicals and transition metal ions chemistry/toxicology and mechanism of synergistic toxicity:

    1. Mechanism of geno-toxicity of wood preservative pentachlorophenol (PCP): Metal-independent  production of hydroxyl/alkoxyl/carbon-centered quinone ketoxy radicals and damage to DNA, protein and lipids

    2. Mechanism of synergistic toxicity between organic and inorganic environmental pollutants: Formation of lipophilic complexes and the role of ROS

    3. The critical role of redox-active transition metal ions in free radical-mediated oxidative damage in  biological systems, and protection by dietary antioxidants

    4. Hydroxyl radical-dependent chemiluminescence emission from halogenated aromatics during advanced oxidation process and applications

    5. Intracellular DNA light switch and fluorescent DNA probe/antitumor agent

    6. Novel free radical and rearrangement reactions activated by polyhalogenated quinoid carcinogens

    Selected publications

    1. Zhu B.Z., Chao X.J., Huang C.H., Li Y. (2016) Delivering the cell-impermeable DNA ‘light-switch’ Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method. Chem. Sci 7:4016-4023 (Cover story)
    Mao, L., Huang, C.H., Gao, H.Y., Kalyanaraman, B., Zhu, B.Z. (2015) Intrinsic chemiluminescence generation during advanced oxidation of persistent halogenated aromatic carcinogens. Environ. Sci. Technol. 49: 7940-7947.
    3. Huang, C.H.; Ren, F.R.; Shan, G.Q.; Qin, H.; Mao, L.; Zhu, B.Z. (2015) Molecular mechanism of metal-independent decomposition of organic hydroperoxides by the halogenated quinoid carcinogens and the potential biological implications. Chem. Res. Toxicol., 28, 831-837.  (Cover story)
    4. Zhu B.Z., Hollenberg PF (2015) Chemical toxicology in China: A special issue. Chem. Res. Toxicol. 28: 279-280. (Guest Editor’s Editorial)
    5. Shan GQ, Yu A, Zhao QF, Huang CH, Zhu LY, Zhu B.Z. (2015) A combined experimental and computational investigation on the unusual molecular mechanism of Lossen rearrangement reaction activated by the carcinogenic halogenated quinones. J. Org. Chem. 80: 180-189.
    6. Li Y, Huang CH, Liu YX, Mao L, Zhu B.Z. (2014) Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure Chemistry-A European Journal, 20(40):13028-33
    7. Huang, C. H.; Shan, G. Q.; Mao, L.; Kalyanaraman, B.; Qin, H.; Ren, F. R.; Zhu, B. Z. (2013) The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct. Chem. Commun. 49: 6436-6438
    8. Qin H, Huang CH, Mao L, Xia HY, Kalyanaraman B, Shao J, Shan GQ, Zhu BZ. (2013) Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic. Biol. Med. 63459-466
    9. Shao J, Huang CH, Kalyanaraman B, Zhu B.Z. (2013) Potent methyl oxidation of 5-methyl-2’-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic. Biol. Med. 60, 177-182
    10. Zhu B.Z., Mao L., Huang C.H., Qin H., Fan R.M., Kalyanaraman B., Zhu J.G. (2012) Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2. Proc. Natl. Acad. Sci. USA 109: 16046-16051.
    11. Sheng Z.G., Zhu B.Z. (2011) Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G-Protein-Coupled Receptor 30 and Estrogen Receptor-α. Environ. Health Perspect. 119: 1775-1780.
    12. Zhu B.Z., Zhu J.G., Kalyanaraman B., Mao L. and Shan G.Q. (2010) Detoxifying polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement. Proc. Natl. Acad. Sci. USA 107: 20286-20290.
    13. Zhu B.Z., Shan G.Q., Huang C.H. and Kalyanaraman B. (2009) Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical. Proc. Natl. Acad. Sci. USA 106: 11466-11471.
    14.  Zhu B.Z., Kalyanaraman B. and Jiang G.B. (2007) Molecular Mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 17575-17578.
    15.  Zhu B.Z., Zhao H.T., Kalyanaraman B. Liu J., Shan G.Q., Du Y.G. and Frei B. (2007) Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. Proc. Natl. Acad. Sci. USA 104: 3698-3702.

    Supported Projects

    1.     Strategic Pilot Project of the Chinese Academy of Sciences: Environmental exposure and health        hazard mechanism of typical pollutants 2014/07-2019/07, B

    2.  General Program of National Natural Science Foundation of China, Study on the molecular mechanism and application of the chemical luminescence of the halide generation in the advanced oxidation process 2015/01-2018/12, chair

    3.   Innovation Group Program of National Natural Science Foundation of China, Environmental   processes and toxic effects of persistent toxic pollutants2014/01-2016/12chair

    4.   Program of National Natural Science Foundation of China, Study on the synergistic toxicity mechanism of organic pesticides and inorganic pesticides containing copper and zinc2013/01-2017/12chair